Evidence map›Paper›PMID 37569633›Full record

ArticleInternational journal of molecular sciences2023

GTS-21 Enhances Regulatory T Cell Development from T Cell Receptor-Activated Human CD4

Masato Mashimo, Takeshi Fujii, Shiro Ono, Yasuhiro Moriwaki, Hidemi Misawa, Tetsushi Azami, Tadashi Kasahara, Koichiro Kawashima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Early effects of α7nAChR regulation on maxillary expansion in mice : A study on osteogenesis and inflammatory factors.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Masato MashimoDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.ORCID 0000-0003-3922-7344
Takeshi FujiiDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe 610-0395, Japan.
Shiro OnoLaboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi 584-8540, Japan.
Yasuhiro MoriwakiDepartment of Pharmacology, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.ORCID 0000-0001-9533-0421
Hidemi MisawaDepartment of Pharmacology, Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan.
Tetsushi AzamiDivision of Gastroenterology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama 227-8502, Japan.
Tadashi KasaharaDivision of Inflammation Research, Jichi Medical University, Shimotsukeshi 324-0498, Japan.
Koichiro KawashimaDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Minato-ku, Tokyo 108-8641, Japan.
Doshisha Women's College of Liberal Arts · JPKeio University · JPJichi Medical University · JPKitasato University · JPOsaka Ohtani University · JPShowa University Fujigaoka Hospital · JP

Funding

Smoking Research Foundation 2021
6 · The paper itself

Abstract

Immune cells such as T cells and macrophages express α7 nicotinic acetylcholine receptors (α7 nAChRs), which contribute to the regulation of immune and inflammatory responses. Earlier findings suggest α7 nAChR activation promotes the development of regulatory T cells (Tregs) in mice. Using human CD4

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorBenzylidene CompoundsCD4-Positive T-LymphocytesPyridinesReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryCell ProliferationHumansLymphocyte ActivationRNA, Messenger3-(2,4-dimethoxybenzylidene)anabaseinealpha7 Nicotinic Acetylcholine ReceptorBenzylidene CompoundsChrna7 protein, humanPyridinesReceptors, Antigen, T-CellRNA, Messengeracetylcholineadoptive immunotherapydupα7GTS-21nAChRTregα7

Identifiers

PMID37569633
PMCPMC10418795
OpenAlexW4385429222

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.