Evidence map›Paper›PMID 37569842›Full record

ArticleInternational journal of molecular sciences2023

Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis.

Xiaoyu Song, Wanfu Wu, Yubing Dai, Margaret Warner, Ivan Nalvarte, Per Antonson, Mukesh Varshney, Jan-Åke Gustafsson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaoyu SongCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.ORCID 0000-0001-9485-977X
Wanfu WuCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Yubing DaiCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Margaret WarnerCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Ivan NalvarteDepartment of Biosciences and Nutrition, Karolinska Institutet, 14186 Huddinge, Sweden.ORCID 0000-0001-6828-2583
Per AntonsonDepartment of Biosciences and Nutrition, Karolinska Institutet, 14186 Huddinge, Sweden.ORCID 0000-0001-9335-9941
Mukesh VarshneyDepartment of Biosciences and Nutrition, Karolinska Institutet, 14186 Huddinge, Sweden.ORCID 0000-0003-2165-0152
Jan-Åke GustafssonCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Karolinska Institutet · SEUniversity of Houston · US

Funding

Robert A. Welch Foundation E-0004
6 · The paper itself

Abstract

Liver X receptors (LXRα and LXRβ) are oxysterol-activated nuclear receptors that play key roles in cholesterol homeostasis, the central nervous system, and the immune system. We have previously reported that LXRαβ-deficient mice are more susceptible to dextran sodium sulfate (DSS)-induced colitis than their WT littermates, and that an LXR agonist protects against colitis in mice mainly via the regulation of the immune system in the gut. We now report that both LXRα and LXRβ are expressed in the colonic epithelium and that in aging LXRαβ

Indexed as

ColitisEstrogen Receptor betaAnimalsColonDextran SulfateIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutReceptors, Cytoplasmic and NuclearDextran SulfateEstrogen Receptor betaReceptors, Cytoplasmic and Nuclearcolitisestrogen receptor βinflammatory bowel diseasesliver X receptorplectin

Identifiers

PMID37569842
PMCPMC10419301
OpenAlexW4385606460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.