Evidence map›Paper›PMID 37569847›Full record

ArticleInternational journal of molecular sciences2023

Quantitative Lipid Profiling Reveals Major Differences between Liver Organoids with Normal Pi*M and Deficient Pi*Z Variants of Alpha-1-antitrypsin.

Sara Pérez-Luz, Jaanam Lalchandani, Nerea Matamala, Maria Jose Barrero, Sara Gil-Martín, Sheila Ramos-Del Saz, Sarai Varona, Sara Monzón, Isabel Cuesta, Iago Justo and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Sara Pérez-LuzMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-0024-6727
Jaanam LalchandaniMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Nerea MatamalaMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Maria Jose BarreroModels and Mechanisms Unit, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-5990-7040
Sara Gil-MartínMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Sheila Ramos-Del SazMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-4831-0353
Sarai VaronaBioinformatics Unit, Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.ORCID 0000-0002-2245-210X
Sara MonzónBioinformatics Unit, Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Isabel CuestaBioinformatics Unit, Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Iago JustoGeneral and Digestive Surgery Department, Hospital 12 de Octubre, 28041 Madrid, Spain.
Alberto MarcacuzcoGeneral and Digestive Surgery Department, Hospital 12 de Octubre, 28041 Madrid, Spain.
Loreto HierroPaediatric Hepatology Service, Research Institute of University Hospital La Paz, (IdiPAZ), 28046 Madrid, Spain.
Cristina GarfiaDigestive Department, Hospital 12 de Octubre, 28041 Madrid, Spain.
Gema Gomez-MarianoMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.
Sabina JanciauskieneDepartment of Respiratory Medicine, Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover Medical School, 30625 Hannover, Germany.
Beatriz Martínez-DelgadoMolecular Genetics and Genetic Diagnostic Units, Institute of Rare Diseases Research (IIER), Spanish National Institute of Health Carlos III (ISCIII), 28220 Madrid, Spain.ORCID 0000-0001-6834-350X
Instituto de Salud Carlos III · ESResearch Institute Hospital 12 de Octubre · ESHospital La Paz Institute for Health Research · ESMedizinische Hochschule Hannover · DE

Funding

Instituto de Salud Carlos III AESI PI20CIII/00015Instituto de Salud Carlos III PT20CIII/00009
6 · The paper itself

Abstract

Different mutations in the

Indexed as

alpha 1-Antitrypsinalpha 1-Antitrypsin DeficiencyHumansLipidsLiver CirrhosisOrganoidsalpha 1-AntitrypsinLipidsAAT aggregatesalpha-1 antitrypsin (AAT)alpha-1 antitrypsin deficiency (AATD)lipid accumulationliver organoids

Identifiers

PMID37569847
PMCPMC10419530
OpenAlexW4385606600

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.