Evidence map›Paper›PMID 37569860›Full record

ArticleInternational journal of molecular sciences2023

Alterations in Mitochondrial Morphology and Quality Control in Primary Mouse Lung Microvascular Endothelial Cells and Human Dermal Fibroblasts under Hyperglycemic Conditions.

Natalia V Belosludtseva, Dmitriy A Serov, Vlada S Starinets, Nikita V Penkov, Konstantin N Belosludtsev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Natalia V BelosludtsevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-5707-6557
Dmitriy A SerovProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov St. 38, 119991 Moscow, Russia.ORCID 0000-0002-6049-5602
Vlada S StarinetsInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Nikita V PenkovInstitute of Cell Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0003-2212-5640
Konstantin N BelosludtsevDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0001-5392-7035
Institute of Theoretical and Experimental Biophysics · RUInstitute of Cell Biophysics · RUMari State University · RUProkhorov General Physics Institute · RU

Funding

Russian Science Foundation 20-15-00120
6 · The paper itself

Abstract

The effect of hyperglycemia on the morphology of individual mitochondria and the state of the mitochondrial network in primary mouse lung microvascular endotheliocytes and human dermal fibroblasts has been investigated. The cells were exposed to high (30 mM) and low (5.5 mM) glucose concentrations for 36 h. In primary endotheliocytes, hyperglycemic stress induced a significant increase in the number of mitochondria and a decrease in the interconnectivity value of the mitochondrial network, which was associated with a decrease in the mean size of the mitochondria. Analysis of the mRNA level of the genes of proteins responsible for mitochondrial biogenesis and mitophagy revealed an increase in the expression level of the

Indexed as

Endothelial CellsFibroblastsHyperglycemiaLungMitochondriaAnimalsCells, CulturedDermisGlucoseGTP PhosphohydrolasesHumansMiceMitochondrial ProteinsMitophagyPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesGlucoseGTP PhosphohydrolasesMitochondrial Proteinsparkin proteinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProtein KinasesUbiquitin-Protein Ligasesdiabetic hyperglycemiamitochondrial biogenesismitochondrial dynamicsmitochondrial dysfunctionmitochondrial morphologymitophagy

Identifiers

PMID37569860
PMCPMC10419261
OpenAlexW4385614934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.