Evidence map›Paper›PMID 37570643›Full record

ReviewMolecules (Basel, Switzerland)2023

Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential.

Siarhei A Dabravolski, Vasily N Sukhorukov, Alexandra A Melnichenko, Victoria A Khotina, Alexander N Orekhov

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06590012 (Prospective Double-Blinded Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Dietary Supplement "Tertinat" on Major Adverse Cardiovascular Events in ATherosclerotic Patients After Coronary Revascularization Surgery.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06590012 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation

Prospective Double-Blinded Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Dietary Supplement "Tertinat" on Major Adverse Cardiovascular Events in ATherosclerotic Patients After Coronary Revascularization Surgery.

TypeinterventionalSponsorInstitute for Atherosclerosis Research, RussiaRan2024 to 2027Enrolled1,228ConditionsAtherosclerosis, Atheroscleroses, Coronary, Carotid AtherosclerosisArmsPlacebo, Tertinat
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Modulation of pro-inflammatory cytokines byJournal of dental sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Siarhei A DabravolskiDepartment of Biotechnology Engineering, Braude Academic College of Engineering, Snunit 51, P.O. Box 78, Karmiel 2161002, Israel.ORCID 0000-0002-0547-6310
Vasily N SukhorukovInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia.ORCID 0000-0002-0312-3773
Alexandra A MelnichenkoInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia.
Victoria A KhotinaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia.ORCID 0000-0003-2096-3237
Alexander N OrekhovInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia.ORCID 0000-0002-3318-4681
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUBraude College of Engineering Karmiel · IL

Funding

Ministry of Science and Higher Education of the Russian Federation Project # FGFU-2022-00008
6 · The paper itself

Abstract

Essential oils (EOs) are complex secondary metabolites identified in many plant species. Plant-derived EOs have been widely used in traditional medicine for centuries for their health-beneficial effects. Some EOs and their active ingredients have been reported to improve the cardiovascular system, in particular to provide an anti-atherosclerotic effect. The objective of this review is to highlight the recent research investigating the anti-inflammatory, anti-oxidative and lipid-lowering properties of plant-derived EOs and discuss their mechanisms of action. Also, recent clinical trials exploring anti-inflammatory and anti-oxidative activities of EOs are discussed. Future research on EOs has the potential to identify new bioactive compounds and invent new effective agents for treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome and obesity.

Indexed as

AtherosclerosisOils, VolatileAnti-Inflammatory AgentsHumansPlant OilsAnti-Inflammatory AgentsOils, VolatilePlant Oilsatherosclerosisendothelial dysfunctionessential oilsinflammationoxidative stress

Identifiers

PMID37570643
PMCPMC10420188
OpenAlexW4385309487

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.