Evidence map›Paper›PMID 37571339›Full record

ArticleNutrients2023

Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation.

Taslima Akter, Md Rakibul Hassan Bulbul, Imran Sama-Ae, M A Azadi, Kamrun Nahar Nira, Salahuddin Quader Al-Araby, Jobaier Ibne Deen, Md Khalid Juhani Rafi, Srabonti Saha, Md Muzahid Ahmed Ezaj and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  3. The Health Benefits ofNutrients · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Taslima AkterDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0009-0001-4398-2003
Md Rakibul Hassan BulbulInstitute for Developing Science and Health Initiatives, ideSHi, Dhaka 1216, Bangladesh.ORCID 0000-0001-6655-3087
Imran Sama-AeSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.ORCID 0000-0001-7644-5311
M A AzadiDepartment of Zoology, University of Chittagong, Chittagong 4331, Bangladesh.
Kamrun Nahar NiraDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
Salahuddin Quader Al-ArabyDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0002-2254-9630
Jobaier Ibne DeenDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0003-3170-7087
Md Khalid Juhani RafiDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0002-5117-6829
Srabonti SahaDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0002-8844-345X
Md Muzahid Ahmed EzajDepartment of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0002-1139-985X
Md Atiar RahmanDepartment of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.ORCID 0000-0002-4902-8923
University of Chittagong · BDBangladesh Institute of Development Studies · BDWalailak University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research investigated the antihypertensive effects of tamarind products and compared their potentials based on an animal model's data verified by molecular docking, multitarget interactions, and dynamic simulation assays. GC-MS-characterized tamarind products were administered to cholesterol-induced hypertensive albino rat models. The two-week-intervened animals were dissected to collect their serum and organs and respectively subjected to analyses of their hypertension-linked markers and tissue architectures. The lead biometabolites of tamarinds interacted with eight target receptors in the molecular docking and dynamic simulation studies and with multitarget in the network pharmacological analyses. The results show that the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), C-reactive protein (CRP), troponin I, and lipid profiles were maximally reinstated by the phenolic-enriched ripened sour tamarind extract compared to the sweet one, but the seed extracts had a smaller influence. Among the tamarind's biometabolites, ϒ-sitosterol was found to be the best ligand to interact with the guanylate cyclase receptor, displaying the best drug-likeliness with the highest binding energy, -9.3 Kcal. A multitargeted interaction-based degree algorithm and a phylogenetic tree of pathways showed that the

Indexed as

HypertensionTamarindusAnimalsAntihypertensive AgentsAntioxidantsGuanylate CyclaseLigandsMolecular Docking SimulationMolecular Dynamics SimulationPhylogenyPlant ExtractsRatsSitosterolsAntihypertensive AgentsAntioxidantsGuanylate CyclaseLigandsPlant ExtractsSitosterolsantihypertensivedynamic simulationgamma-sitosterolnetwork pharmacologyTamarindus indicatroponin I

Identifiers

PMID37571339
PMCPMC10420995
OpenAlexW4385429099

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.