Evidence map›Paper›PMID 37575875›Full record

ArticleBioactive materials2023

Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct.

In-Kyu Lee, Ruosen Xie, Agustin Luz-Madrigal, Seunghwan Min, Jingcheng Zhu, Jiahe Jin, Kimberly L Edwards, M Joseph Phillips, Allison L Ludwig, David M Gamm and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Cell therapy for age-related macular degeneration.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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  3. Article
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  8. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
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  10. Atrophic Macular Degeneration and Stem Cell Therapy: A Clinical Review.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

In-Kyu LeeDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Ruosen XieWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Agustin Luz-MadrigalMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Seunghwan MinDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jingcheng ZhuWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Jiahe JinWaisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Kimberly L EdwardsWaisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
M Joseph PhillipsWaisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Allison L LudwigMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, 53705, USA.
David M GammDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Shaoqin GongWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Zhenqiang MaDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) causes blindness due to loss of retinal pigment epithelium (RPE) and photoreceptors (PRs), which comprise the two outermost layers of the retina. Given the small size of the macula and the importance of direct contact between RPE and PRs, the use of scaffolds for targeted reconstruction of the outer retina in later stage AMD and other macular dystrophies is particularly attractive. We developed microfabricated, honeycomb-patterned, biodegradable poly(glycerol sebacate) (PGS) scaffolds to deliver organized, adjacent layers of RPE and PRs to the subretinal space. Furthermore, an optimized process was developed to photocure PGS, shortening scaffold production time from days to minutes. The resulting scaffolds robustly supported the seeding of human pluripotent stem cell-derived RPE and PRs, either separately or as a dual cell-layered construct. These advanced, economical, and versatile scaffolds can accelerate retinal cell transplantation efforts and benefit patients with AMD and other retinal degenerative diseases.

Indexed as

MicrofabricationRetinaScaffoldsStem cellsTissue engineering

Identifiers

PMID37575875
PMCPMC10415596
OpenAlexW4385439347

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.