Evidence map›Paper›PMID 37575972›Full record

ArticlePhotoacoustics2023

Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation:

Rayyan Manwar, Karl Kratkiewicz, Sadreddin Mahmoodkalayeh, Ali Hariri, Christos Papadelis, Anne Hansen, De-Ann M Pillers, Juri Gelovani, Kamran Avanaki

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07784179 (Ultrasound and Photoacoustic Imaging of Hydrocephalus), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07784179 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Ultrasound and Photoacoustic Imaging of Hydrocephalus

TypeinterventionalSponsorMichael McDowellRan2026 to 2029Enrolled250ConditionsHydrocephalus in Infants, Hydrocephalus in ChildrenArmsPAUS imaging
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The neurobiological regulatory mechanism of brain edema.Frontiers in cellular neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Non-Invasive Photoacoustic Cerebrovascular Monitoring of Early-Stage Ischemic Strokes In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Rayyan ManwarUniversity of Illinois at Chicago, Department of Biomedical Engineering, Chicago, IL, United States.
Karl KratkiewiczBarbara Ann Karmanos Cancer Institute, Detroit, MI, United States.
Sadreddin MahmoodkalayehDepartment of Physics, Shahid Beheshti University, Tehran, Iran.
Ali HaririDepartment of Nanoengineering, University of California, San Diego, CA, United States.
Christos PapadelisJane and John Justin Neurosciences Center, Cook Children's Health Care System, Fort Worth, TX, United States.
Anne HansenDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
De-Ann M PillersDepartment of Pediatrics, UI Health Children's Hospital of the University of Illinois at Chicago, Chicago, IL, United States.
Juri GelovaniCollege of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, UAE.
Kamran AvanakiUniversity of Illinois at Chicago, Department of Biomedical Engineering, Chicago, IL, United States.
University of Illinois Chicago · USBoston Children's Hospital · USShahid Beheshti University · IRSiriraj Hospital · THThe Barbara Ann Karmanos Cancer Institute · USThe University of Texas at Arlington · USUniversity of California San Diego · US

Funding

Transfontanelle photoacoustic imaging to study pathophysiology of neonatal braininjuryR01EB027769 · NIBIB · WAYNE STATE UNIVERSITY · PI AVANAKI, KAMRAN · 2019 to 2023
$1.7M
In vivo photoacoustic imaging of prefrontal cortex in rats undergoing fentanyl self-administrationR21DA052657 · NIDA · WAYNE STATE UNIVERSITY · PI AVANAKI, KAMRAN, PERRINE, SHANE ALAN · 2021 to 2022
$415k
NIBIB NIH HHS R01 EB027769NIDA NIH HHS R21 DA052657
6 · The paper itself

Abstract

We have developed and optimized an imaging system to study and improve the detection of brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for brain imaging in neonates through the skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The system is optimized in terms of optical and acoustic designs, thermal safety, and mechanical stability. The lower limit of quantification of TFPAI to detect the location of hemorrhage and its size is evaluated using in-vitro and

Indexed as

HemorrhageNeonatesOxygenationPhotoacoustic imagingTransfontanelle

Identifiers

PMID37575972
PMCPMC10413353
OpenAlexW4385298854

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.