Evidence map›Paper›PMID 37575987›Full record

ReviewFrontiers in medicine2023

Endothelial dysfunction in autoimmune, pulmonary, and kidney systems, and exercise tolerance following SARS-CoV-2 infection.

Sabyasachi Sen, Shikha Khosla, Omar Awan, Scott Cohen, Jared M Gollie

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sabyasachi SenDivision of Endocrinology, Department of Medicine, Veterans Affairs Medical Center, Washington, DC, United States.
Shikha KhoslaDivision of Endocrinology, Department of Medicine, Veterans Affairs Medical Center, Washington, DC, United States.
Omar AwanDivision of Pulmonary Medicine, Department of Medicine, Veterans Affairs Medical Center, Washington, DC, United States.
Scott CohenDivision of Nephrology, Department of Medicine, Veterans Affairs Medical Center, Washington, DC, United States.
Jared M GollieResearch and Development Service, Veterans Affairs Medical Center, Washington, DC, United States.
Veterans Health Administration · USGeorge Washington University · US

Funding

Fatigue and Fatigability in Veterans Following SARS-CoV-2 InfectionI21RX004371 · VA · U.S. DEPT/VETS AFFAIRS MEDICAL CENTER · PI GOLLIE, JARED M. · 2023 to 2024
–
RRD VA I21 RX004371RRD VA IK2 RX003423
6 · The paper itself

Abstract

Long COVID is characterized by persistent symptoms beyond 3-months of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection that last for at least 2 months and cannot be explained by an alternative diagnosis. Autonomic, immunologic, endothelial, and hypercoagulation are implicated as possible mechanisms of long COVID symptoms. Despite recognition of the public health challenges posed by long COVID, the current understanding of the pathophysiological underpinnings is still evolving. In this narrative review, we explore the long-term effects of SARS-CoV-2 infection on T cell activation such as autoimmune disorders and endothelial cell dysfunction involving vascular impairments within pulmonary and renal architecture. We have described how endothelial dysfunction and vascular abnormalities may underscore findings of exercise intolerance by way of impaired peripheral oxygen extraction in individuals with long COVID.

Indexed as

A-vO2 differencediffusion capacity (DLco)endocrine disordersendothelial (dys)functionkidney insufficiencypost-acute and long COVID symptoms

Identifiers

PMID37575987
PMCPMC10413142
OpenAlexW4385302908

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.