Evidence map›Paper›PMID 37576681›Full record

ReviewACS omega2023

Neurological Sequelae of COVID-19: A Biochemical Perspective.

Xiaoxiao Zhang, Ying Zhang, Ling Wen, Jess Lan Ouyang, Weiwei Zhang, Jiaming Zhang, Yuchuan Wang, Qiuyun Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Role of Divalent Cations in Infections in Host-Pathogen Interaction.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaoxiao ZhangSchool of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Ying ZhangGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
Ling WenGI Medicine, Guangzhou Twelfth People's Hospital, Guangzhou 510620, Guangdong, China.
Jess Lan OuyangSchool of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Weiwei ZhangSchool of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Jiaming ZhangSchool of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Yuchuan WangSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063210, China.ORCID https://orcid.org/0000-0002-1137-9744
Qiuyun LiuSchool of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID https://orcid.org/0000-0001-5533-0128
Sun Yat-sen University · CNGuangzhou Center for Disease Control and Prevention · CNNorth China University of Science and Technology · CNTwelfth Guangzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein expression profile by enabling the efficient synthesis of proteins rich in amino acids with calcium affinity. Subsequent formation of insoluble and stiff calcium oxalate and aggregates confers cellular stress and causes cell senescence. This scenario accounts for sequelae seen in some patients following recovery from COVID-19.

Identifiers

PMID37576681
PMCPMC10413374
OpenAlexW4385245668

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.