Evidence map›Paper›PMID 37577082›Full record

ArticleJournal of biomedical optics2023

Iterative prototyping based on lessons learned from the falloposcope

Andrew D Rocha, William K Drake, Photini F Rice, Dilara J Long, Hasina Shir, Ryan H M Walton, Mary N Reed, Dominique Galvez, Taliah Gorman, John M Heusinkveld and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrew D RochaThe University of Arizona, Wyant College of Optical Science, Tucson, Arizona, United States.ORCID 0000-0002-9030-7609
William K DrakeThe University of Arizona, Wyant College of Optical Science, Tucson, Arizona, United States.
Photini F RiceThe University of Arizona, Biomedical Engineering Department, Tucson, Arizona, United States.
Dilara J LongThe University of Arizona, Biomedical Engineering Department, Tucson, Arizona, United States.ORCID 0000-0002-5564-4773
Hasina ShirThe University of Arizona, Biomedical Engineering Department, Tucson, Arizona, United States.
Ryan H M WaltonThe University of Arizona, Biomedical Engineering Department, Tucson, Arizona, United States.
Mary N ReedThe University of Arizona, Clinical and Translational Services, Tucson, Arizona, United States.
Dominique GalvezThe University of Arizona, Wyant College of Optical Science, Tucson, Arizona, United States.ORCID 0000-0002-7716-7250
Taliah GormanThe University of Arizona, Biomedical Engineering Department, Tucson, Arizona, United States.
John M HeusinkveldThe University of Arizona, Department of Obstetrics and Gynecology, Tucson, Arizona, United States.ORCID 0000-0002-5708-2647
Jennifer K BartonThe University of Arizona, Wyant College of Optical Science, Tucson, Arizona, United States.ORCID 0000-0003-4897-9361
University of Arizona · US

Funding

Ovarian Cancer Detection with Blood- and Imaging-Based BiomarkersR01CA260399 · NCI · UNIVERSITY OF ARIZONA · PI Jennifer Kehlet Barton, David A. Fishman · 2022 to 2026
$3.9M
NCI NIH HHS R01 CA260399
6 · The paper itself

Abstract

Significance: High grade serous ovarian cancer is the most deadly gynecological cancer, and it is now believed that most cases originate in the fallopian tubes (FTs). Early detection of ovarian cancer could double the 5-year survival rate compared with late-stage diagnosis. Autofluorescence imaging can detect serous-origin precancerous and cancerous lesions in Aim: We developed an FT endoscope, the falloposcope, as a method for detecting ovarian cancer with MFI and OCT. The falloposcope clinical prototype was tested in a pilot study with 12 volunteers to date to evaluate the safety and feasibility of FT imaging prior to standard of care salpingectomy in normal-risk volunteers. In this manuscript, we describe the multiple modifications made to the falloposcope to enhance robustness, usability, and image quality based on lessons learned in the clinical setting. Approach: The Results: The falloposcope successfully obtained images Conclusions: The initial clinical prototype falloposcope was able to image the FTs, and iterative prototyping has increased its robustness, functionality, and ease of use for future trials.

Indexed as

Fallopian TubesOvarian NeoplasmsEndoscopesFemaleHumansPilot Projectsendoscopic optical coherence tomographyfallopian tubein vivo imagingmicroendoscope iterative design and prototypingmultispectral fluorescence imagingovarian cancer

Identifiers

PMID37577082
PMCPMC10423010
OpenAlexW4385774212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.