Evidence map›Paper›PMID 37577144›Full record

ArticleOncoimmunology2023

L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes.

Stephanie Schlichtner, Inna M Yasinska, Elena Klenova, Maryam Abooali, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F Gibbs and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

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  11. The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  20. Deciphering the immunomodulatory mechanisms ofFrontiers in cell and developmental biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Stephanie SchlichtnerMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Inna M YasinskaMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Elena KlenovaSchool of Biological Sciences, University of Essex, Colchester, UK.
Maryam AbooaliMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Gurprit S LallMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Steffen M BergerDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Sabrina RuggieroDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Dietmar CholewaDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Milan MiloševićDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Bernhard F GibbsMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Elizaveta Fasler-KanDepartment of Pediatric Surgery, Children's Hospital, Inselspital Bern, University of Bern and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Vadim V SumbayevMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Medway School of Pharmacy · GBUniversity Children’s Hospital Bern · CHUniversity of Bern · CHHeidelberg University · DEUniversity Hospital of Bern · CHUniversity of Essex · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino acid L-kynurenine (LKU), could also substantially contribute to the suppression of anti-cancer immunity. However, the biochemical mechanisms underlying the suppressive effects of LKU on T-cells remain unclear. Here, we report for the first time that LKU suppresses T cell function as an aryl hydrocarbon receptor (AhR) ligand. The presence of LKU in T cells is associated with AhR activation, which results in competition between AhR and hypoxia-inducible factor 1 alpha (HIF-1α) for the AhR nuclear translocator, ARNT, leading to T cell exhaustion. The expression of indoleamine 2,3-dioxygenase 1 (IDO1, the enzyme that leads to LKU generation) is induced by the TGF-β-Smad-3 pathway. We also show that IDO-negative cancers utilize an alternative route for LKU production

Indexed as

KynurenineNeoplasmsHumansImmune EvasionSignal TransductionT-LymphocytesTumor MicroenvironmentKynureninecancerimmune checkpointsimmune escapekynurenineT cells

Identifiers

PMID37577144
PMCPMC10416736
OpenAlexW4385737831

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.