Evidence map›Paper›PMID 37577190›Full record

ReviewVeterinary world2023

Virulence factors and quorum sensing as targets of new therapeutic options by plant-derived compounds against bacterial infections caused by human and animal pathogens.

Warangkana Kitpipit, C Norman Scholfield, Suthinee Sangkanu, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Alok K Paul, Watcharapong Mitsuwan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Veterinary world, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Assessment of the Antimicrobial Activity ofInternational journal of molecular sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Warangkana KitpipitAkkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
C Norman ScholfieldAkkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Suthinee SangkanuSchool of Allied Health Sciences, Southeast Asia Water Team, World Union for Herbal Drug Discovery, and Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Veeranoot NissapatornSchool of Allied Health Sciences, Southeast Asia Water Team, World Union for Herbal Drug Discovery, and Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Maria de Lourdes PereiraDepartment of Medical Sciences, CICECO-Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal.
Alok K PaulSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia.
Watcharapong MitsuwanAkkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Walailak University · THUniversity of Aveiro · PTUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of antibiotic-resistant bacteria and hospital-acquired bacterial infection has become rampant due to antibiotic overuse. Virulence factors are secondary to bacterial growth and are important in their pathogenesis, and therefore, new antimicrobial therapies to inhibit bacterial virulence factors are becoming important strategies against antibiotic resistance. Here, we focus on anti-virulence factors that act through anti-quorum sensing and the subsequent clearance of bacteria by antimicrobial compounds, especially active herbal extracts. These quorum sensing systems are based on toxins, biofilms, and efflux pumps, and bioactive compounds isolated from medicinal plants can treat bacterial virulence pathologies. Ideally, bacterial virulence factors are secondary growth factors of bacteria. Hence, inhibition of bacterial virulence factors could reduce bacterial pathogenesis. Furthermore, anti-virulence factors from herbal compounds can be developed as novel treatments for bacterial infection. Therefore, this narrative review aims to discuss bacterial virulence factors acting through quorum sensing systems that are preserved as targets for treating bacterial infection by plant-derived compounds.

Indexed as

antibiotic resistancepathogensphytochemicalsquorum sensing systemvirulence factors

Identifiers

PMID37577190
PMCPMC10421536
OpenAlexW4381432795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.