Evidence map›Paper›PMID 37577708›Full record

ArticleResearch square2023

Accumulation of F-actin drives brain aging and limits healthspan in

Edward T Schmid, Joseph M Schinaman, Kylie S Williams, David W Walker

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Edward T SchmidDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Joseph M SchinamanDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Kylie S WilliamsDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.
David W WalkerDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California 90095, USA.ORCID 0000-0002-9422-2178
University of California, Los Angeles · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Role of Mitochondrial Homeostasis in Animal AgingR01AG037514 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David W Walker · 2010 to 2026
$5.3M
Role of Intestinal Homeostasis in Organismal AgingRF1AG049157 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALKER, DAVID W · 2021 to 2021
$1.2M
NIA NIH HHS R01 AG037514NIA NIH HHS RF1 AG049157NIH HHS P40 OD018537
6 · The paper itself

Abstract

The actin cytoskeleton is a key determinant of cell and tissue homeostasis. However, tissue-specific roles for actin dynamics in aging, notably brain aging, are not understood. Here, we show that there is an age-related increase in filamentous actin (F-actin) in

Indexed as

FhosLifespanMitophagyproteostasis

Identifiers

PMID37577708
PMCPMC10418561
OpenAlexW4385408325

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.