Evidence map›Paper›PMID 37578579›Full record

ArticleCell stress & chaperones2023

LED therapy plus idebenone treatment targeting calcium and mitochondrial signaling pathways in dystrophic muscle cells.

Heloina Nathalliê Mariano da Silva, Daniela Sayuri Mizobuti, Valéria Andrade Pereira, Guilherme Luiz da Rocha, Marcos Vinícius da Cruz, André Gustavo de Oliveira, Leonardo Reis Silveira, Elaine Minatel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Heloina Nathalliê Mariano da SilvaDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Daniela Sayuri MizobutiDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Valéria Andrade PereiraDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Guilherme Luiz da RochaDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Marcos Vinícius da CruzDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
André Gustavo de OliveiraDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Leonardo Reis SilveiraDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.
Elaine MinatelDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil. minatel@unicamp.br.ORCID 0000-0001-9863-0761
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 140845/2020-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 303471/2022-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/09733-4
6 · The paper itself

Abstract

Intracellular calcium dysregulation, oxidative stress, and mitochondrial dysfunction are some of the main pathway contributors towards disease progression in Duchenne muscular dystrophy (DMD). This study is aimed at investigating the effects of light emitting diode therapy (LEDT) and idebenone antioxidant treatment, applied alone or together in dystrophic primary muscle cells from mdx mice, the experimental model of DMD. Mdx primary muscle cells were submitted to LEDT and idebenone treatment and evaluated for cytotoxic effects and calcium and mitochondrial signaling pathways. LEDT and idebenone treatment showed no cytotoxic effects on the dystrophic muscle cells. Regarding the calcium pathways, after LEDT and idebenone treatment, a significant reduction in intracellular calcium content, calpain-1, calsequestrin, and sarcolipin levels, was observed. In addition, a significant reduction in oxidative stress level markers, such as H

Indexed as

CalciumMuscle, SkeletalAnimalsDisease Models, AnimalHydrogen PeroxideMiceMice, Inbred C57BLMice, Inbred mdxMuscle CellsSignal TransductionUbiquinoneCalciumHydrogen PeroxideidebenoneUbiquinoneCalcium signalingDystrophic muscle cellsMitochondrial parametersOxidative stressPhotobiomodulation

Identifiers

PMID37578579
PMCPMC10746663
OpenAlexW4385798038

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.