Evidence map›Paper›PMID 37579140›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Evolutionary history of MEK1 illuminates the nature of deleterious mutations.

Ekaterina P Andrianova, Robert A Marmion, Stanislav Y Shvartsman, Igor B Zhulin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ekaterina P AndrianovaDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-3719-0293
Robert A MarmionThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-3895-0584
Stanislav Y ShvartsmanThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.
Igor B ZhulinDepartment of Microbiology, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-6708-5323
Princeton University · USThe Ohio State University · US

Funding

Computational Genomics of Signal TransductionR35GM131760 · NIGMS · OHIO STATE UNIVERSITY · PI Igor B. Jouline · 2019 to 2026
$3.2M
Systems biology of MAPK signaling in early drosophila embryoR01GM086537 · NIGMS · PRINCETON UNIVERSITY · PI BURDINE, REBECCA D., GOLDSMITH, ELIZABETH J. · 2011 to 2018
$3.1M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01GM141843 · NIGMS · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM086537NIGMS NIH HHS R01 GM134204NIGMS NIH HHS R01 GM141843NIGMS NIH HHS R35 GM131760
6 · The paper itself

Abstract

Mutations in signal transduction pathways lead to various diseases including cancers. MEK1 kinase, encoded by the human

Indexed as

Ectodermal DysplasiaHeart Defects, CongenitalAmino AcidsAnimalsHumansMAP Kinase Kinase 1MutationMutation, MissenseAmino AcidsMAP Kinase Kinase 1damaging mutationsDrosophilaserine–threonine kinasevariants of unknown significance

Identifiers

PMID37579140
PMCPMC10450672
OpenAlexW4385802825

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.