Evidence map›Paper›PMID 37579593›Full record

ArticleAtherosclerosis2023

Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT.

Andy Hon, Jeffrey J Hsu, Angelica Zambrano, Yuxuan Xia, Mimi Lu, David Echeverri, Sophia Kalanski, Soban Umar, Linda L Demer, Yin Tintut

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Effects of LP533401 on vascular and bone calcification in hyperlipidemic mice.Biochemical and biophysical research communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Andy HonDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jeffrey J HsuDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Veterans Affairs Greater Los Angeles HealthCare System, Los Angeles, CA, USA.
Angelica ZambranoPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Yuxuan XiaDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Mimi LuDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
David EcheverriDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sophia KalanskiDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Soban UmarDepartments of Anesthesiology, University of California, Los Angeles, Los Angeles, CA, USA.
Linda L DemerDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Departments of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA; Departments of Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Yin TintutDepartments of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Veterans Affairs Greater Los Angeles HealthCare System, Los Angeles, CA, USA; Departments of Physiology, University of California, Los Angeles, Los Angeles, CA, USA; Departments of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: ytintut@mednet.ucla.edu.
University of California, Los Angeles · USTexas Tech University · US

Funding

Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcificationR01HL151391 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2021 to 2024
$2.2M
Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertensionR01HL161038 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Soban Umar · 2022 to 2026
$1.9M
Serotonin receptor contribution to inflammation-induced calcific aortic valve diseaseR01HL137647 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2019 to 2022
$1.6M
Mechanisms of intermittent parathyroid hormone effects on calcific aortic diseaseR01HL121019 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEMER, LINDA L., TINTUT, YIN · 2015 to 2018
$1.5M
Role of the Novel MicroRNA-125b in Pulmonary Hypertension Associated with Pulmonary FibrosisK08HL141995 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI UMAR, SOBAN · 2019 to 2023
$879k
Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular CalcificationK08HL151961 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSU, JEFFREY JOHN · 2020 to 2024
$646k
NHLBI NIH HHS K08 HL141995NHLBI NIH HHS K08 HL151961NHLBI NIH HHS R01 HL137647NHLBI NIH HHS R01 HL151391NHLBI NIH HHS R01 HL161038
6 · The paper itself

Abstract

BACKGROUND AND

aimsCardiovascular disease risk is associated with coronary artery calcification and is mitigated by regular exercise. Paradoxically, elite endurance athletes, who have low risk, are likely to have more coronary calcification, raising questions about the optimal level of activity.

methodsFemale hyperlipidemic (Apoe

resultsIn controls, aortic calcium content and density increased significantly. Exercise regimens did not alter the time-dependent increase in content, but the increase in mean density was blunted. Interestingly, the low-speed regimen significantly reduced

conclusionsThese results suggest that, in mice, exercise has differential effects on aortic calcification, cardiac function, and skeletal bone mineral density.

Indexed as

CalcinosisCoronary Artery DiseaseAnimalsAortaEchocardiographyFemaleMaleMiceCalcificationCTExerciseHyperlipidemiaImagingPET

Identifiers

PMID37579593
PMCPMC11146201
OpenAlexW4385480987

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.