Evidence map›Paper›PMID 37580916›Full record

ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2023

Physiologic hormone administration improves HbA1C in Native Americans with type 2 diabetes: A retrospective study and review of insulin secretion and action.

Candida J Rebello, Tyler S Morales, Katsya Chuon, Shu Dong, V Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A Beyl, Frank L Greenway

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216665 (Effect of Pulsatile Hormone Administration on Insulin Action), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06216665 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Pulsatile Hormone Administration on Insulin Action

TypeinterventionalSponsorPennington Biomedical Research CenterRan2024 to 2025Enrolled12ConditionsInsulin SensitivityArmsContinuous Insulin administration during hyperinsulinemic euglycemic clamp test, Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Candida J RebelloNutrition and Chronic Disease, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID 0000-0002-7335-9095
Tyler S MoralesFirst American Wellness, Banning, California, USA.
Katsya ChuonFirst American Wellness, Banning, California, USA.
Shu DongFirst American Wellness, Banning, California, USA.
V Tyrone LamFirst American Wellness, Banning, California, USA.
Dan PurnerFirst American Wellness, Banning, California, USA.
Stanley LewisEselle Health, Inc., La Jolla, California, USA.
Jonathan LakeyDepartment of Surgery, University of California Irvine, Irvine, California, USA.
Robbie A BeylBiostatistics, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Frank L GreenwayClinical Trials Unit, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID 0000-0002-1766-6111
First American (United States) · USPennington Biomedical Research Center · USLa Jolla Alcohol Research · USUniversity of California, Irvine · US

Funding

Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
NIA NIH HHS R00 AG065419NIA NIH HHS R00AG065419NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Insulin is secreted in pulses from pancreatic beta-cells, and these oscillations maintain fasting plasma glucose levels within a narrow normal range. Within islets, beta-cells exhibit tight synchronization of regular oscillations. This control circuit is disrupted in type 2 diabetes, and irregularities in pulse frequency and amplitude occur. The prevalence of type 2 diabetes is three times higher in American Indian and Native Alaskans compared to Whites, and their genetic ancestry is associated with low beta-cell function. Obesity in this population compounds their vulnerability to adverse outcomes. The purpose of this article is to review insulin secretion and action and its interaction with race. We also present the results from a 6-month retrospective chart review of metabolic outcomes following intravenous physiologic hormone administration to 10 Native Americans. We found reductions in hemoglobin A1C (baseline: 9.03% ± 2.08%, 6 months: 7.03% ± 0.73%, p = 0.008), fasting glucose (baseline: 176.0 ± 42.85 mg/dL, 6 months: 137.11 ± 17.05 mg/dL, p = 0.02), homeostatic model assessment of insulin resistance (baseline: 10.39 ± 4.66, 6 months: 7.74 ± 4.22, p = 0.008), and triglycerides (baseline: 212.20 ± 101.44, 6 months: 165.50 ± 76.48 mg/dL, p = 0.02). Physiologic hormone administration may improve components of the metabolic syndrome. The therapy warrants investigation in randomized controlled trials.

Indexed as

Diabetes Mellitus, Type 2American Indian or Alaska NativeBlood GlucoseGlycated HemoglobinHumansInsulinInsulin SecretionRetrospective StudiesBlood GlucoseGlycated HemoglobinInsulinHbA1CNative Americanspulsatile insulin secretiontype 2 diabetes

Identifiers

PMID37580916
PMCPMC10879952
OpenAlexW4385827753

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.