Evidence map›Paper›PMID 37580962›Full record

ArticleeLife2023

Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (

Mengyao Wu, Tak-Ho Lo, Liping Li, Jia Sun, Chujun Deng, Ka-Ying Chan, Xiang Li, Steve Ting-Yuan Yeh, Jimmy Tsz Hang Lee, Pauline Po Yee Lui and 2 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. The novel adipokine Placin regulates glucose homeostasis via insulin secretion and IGF1 receptor signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Review
  4. Review
  5. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Oligonucleotide therapies for nonalcoholic steatohepatitis.Molecular therapy. Nucleic acids · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Mengyao WuDepartment of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5748-5780
Tak-Ho LoDepartment of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Liping LiZhujiang Hospital, Southern Medical University, China, China.
Jia SunZhujiang Hospital, Southern Medical University, China, China.
Chujun DengDepartment of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Ka-Ying ChanDepartment of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Xiang LiDepartment of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.
Steve Ting-Yuan YehIonis Pharmaceuticals, Carlsbad, United States.
Jimmy Tsz Hang LeeDepartment of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Pauline Po Yee LuiDepartment of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0003-2446-6203
Aimin XuDepartment of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Chi-Ming WongDepartment of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0002-0025-7135
Hong Kong Polytechnic University · HKUniversity of Hong Kong · HKZhujiang Hospital · CNChinese University of Hong Kong · HKGuangzhou University · CNIonis Pharmaceuticals (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent research has shown that the adhesion G protein-coupled receptor F1 ( Methods: We used recombinant adeno-associated virus-mediated gene delivery system, and antisense oligonucleotide was used to manipulate the hepatic Results: The expression of Conclusions: These results indicate Funding: This work was supported by the National Natural Science Foundation of China (81870586), Area of Excellence (AoE/M-707/18), and General Research Fund (15101520) to CMW, and the National Natural Science Foundation of China (82270941, 81974117) to SJ.

Indexed as

Non-alcoholic Fatty Liver DiseaseReceptors, G-Protein-CoupledAnimalsDiet, High-FatLipid MetabolismLiverMiceMice, Inbred C57BLMice, ObeseObesityADGRF1 protein, mouseReceptors, G-Protein-Coupledcell biologyfatty livergpr110humanlipid metabolismmedicinemouseobesitySCD1

Identifiers

PMID37580962
PMCPMC10427146
OpenAlexW4385827878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.