Evidence map›Paper›PMID 37581221›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

P2X

Elizabeth A Townsend, Arturo Guadarrama, Lei Shi, Elon Roti Roti, Loren C Denlinger

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. The P2X7 Receptor Regulates IL-1β Secretion in the Human Retina.International journal of molecular sciences · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Macrophage Dysfunction in Respiratory Disease.Results and problems in cell differentiation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elizabeth A TownsendDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0003-4957-6628
Arturo GuadarramaDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
Lei ShiDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
Elon Roti RotiDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.ORCID 0000-0002-0526-9223
Loren C DenlingerDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Pamela K Kreeger · 1985 to 2026
$142.6M
Nucleotide receptor modulation of airway eicosanoids during asthma exacerbationsR01HL115118 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DENLINGER, LOREN C · 2013 to 2017
$2.4M
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL115118
6 · The paper itself

Abstract

Few new therapeutics exist to target airway inflammation in mild-to-moderate asthma. Alveolar macrophages regulate airway inflammation by producing proresolving eicosanoids. We hypothesized that stimulation of the purinergic receptor P2X

Indexed as

AsthmaMacrophages, AlveolarAdamantaneBenzamidesEicosanoidsHumansHydroxyeicosatetraenoic AcidsInflammationAdamantaneAZD9056BenzamidesEicosanoidsHydroxyeicosatetraenoic Acidsasthmaeicosanoidinflammationlipoxinpurinergic

Identifiers

PMID37581221
PMCPMC10639011
OpenAlexW4385827777

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.