Evidence map›Paper›PMID 37585288›Full record

ArticleMolecular biology of the cell2023

Hydrostatic Pressure Sensing by WNK kinases.

John M Humphreys, Liliana R Teixeira, Radha Akella, Haixia He, Ashari R Kannangara, Kamil Sekulski, John Pleinis, Joanna Liwocha, Jenny Jiou, Kelly A Servage and 7 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

John M HumphreysDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4770-975X
Liliana R TeixeiraDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.
Radha AkellaDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1488-1091
Haixia HeDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-9237-3474
Ashari R KannangaraDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-3100-9676
Kamil SekulskiDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-6453-252X
John PleinisDepartment of Internal Medicine, Division of Nephrology and Hypertension and Department of Human Genetics, University of Utah, Salt Lake City UT 84112.
Joanna LiwochaDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jenny JiouDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2124-5272
Kelly A ServageDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-7183-2865
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-0678-7620
Lukasz JoachimiakCenter for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-3061-5850
Josep RizoDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1773-8311
Melanie H CobbDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-0833-5473
Chad A BrautigamDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6563-1338
Aylin R RodanDepartment of Internal Medicine, Division of Nephrology and Hypertension and Department of Human Genetics, University of Utah, Salt Lake City UT 84112.ORCID 0000-0001-9202-2378
Elizabeth J GoldsmithDepartment of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-8102-5012
The University of Texas Southwestern Medical Center · USUniversity of Utah · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK110358NIH HHS P40 OD018537
6 · The paper itself

Abstract

Previous study has demonstrated that the WNK kinases 1 and 3 are direct osmosensors consistent with their established role in cell-volume control. WNK kinases may also be regulated by hydrostatic pressure. Hydrostatic pressure applied to cells in culture with N

Indexed as

Protein Serine-Threonine KinasesAnimalsHydrostatic PressurePhosphorylationProtein Serine-Threonine Kinases

Identifiers

PMID37585288
PMCPMC10559305
OpenAlexW4385878972

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.