Evidence map›Paper›PMID 37586449›Full record

ArticleActa biomaterialia2023

Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines.

Paresh C Shrimali, Sheng Chen, Anirban Das, Rachel Dreher, Matthew K Howard, Jeremy J Ryan, Jeremy Buck, Darren Kim, Macy L Sprunger, Jai S Rudra and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Nano-Emulsion Incorporating Squalene and MnInternational journal of nanomedicine · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Paresh C ShrimaliDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
Sheng ChenDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Anirban DasDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA; Department of Chemistry, Washington University, St. Louis, MO 63130, USA.
Rachel DreherDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Matthew K HowardDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Jeremy J RyanDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Jeremy BuckDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
Darren KimDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
Macy L SprungerDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA.
Jai S RudraDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. Electronic address: srudra22@wustl.edu.
Meredith E JackrelDepartment of Chemistry, Washington University, St. Louis, MO 63130, USA. Electronic address: mjackrel@wustl.edu.
Washington University in St. Louis · US

Funding

Amyloid-inspired Vaccine Delivery for the ElderlyR21AG068733 · NIA · WASHINGTON UNIVERSITY · PI JACKREL, MEREDITH E., RUDRA, JAI · 2021 to 2022
$630k
NIA NIH HHS R21 AG068733
6 · The paper itself

Abstract

De novo designed peptides that self-assemble into cross-β rich fibrillar biomaterials have been pursued as an innovative platform for the development of adjuvant- and inflammation-free vaccines. However, they share structural and morphological properties similar to amyloid species implicated in neurodegenerative diseases, which has been a long-standing concern for their successful translation. Here, we comprehensively characterize the amyloidogenic character of the amphipathic self-assembling cross-β peptide KFE

Indexed as

Vaccines, DNAAdjuvants, ImmunologicAnimalsBiocompatible MaterialsCD8-Positive T-LymphocytesMammalsMicePeptidesAdjuvants, ImmunologicBiocompatible MaterialsPeptidesVaccines, DNAAmyloidImmune responsePeptide nanofiberSelf-assemblyVaccineYeast

Identifiers

PMID37586449
PMCPMC12516588
OpenAlexW4385804315

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.