Evidence map›Paper›PMID 37587178›Full record

ArticleNature communications2023

Ultra-wideband optical coherence elastography from acoustic to ultrasonic frequencies.

Xu Feng, Guo-Yang Li, Seok-Hyun Yun

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xu Feng *Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St. BAR-8, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-9048-7144
Guo-Yang Li *Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St. BAR-8, Boston, MA, 02114, USA.
Seok-Hyun YunHarvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St. BAR-8, Boston, MA, 02114, USA. syun@hms.harvard.edu.ORCID http://orcid.org/0000-0002-8903-5909

Funding

Multi-Scale Integration of Extracellular Matrix Mechanics in Vascular RemodelingR01HL098028 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI ZHANG, YANHANG KATHERINE · 2011 to 2025
$5.2M
Development of stimulated Brillouin microscopy for high-resolution stiffness measurementR01EB027653 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2019 to 2023
$2.0M
In vivo optical coherence elastography of the cornea: mapping shear and tensile moduliR01EY033356 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2022 to 2024
$1.2M
NEI NIH HHS R01 EY033356NHLBI NIH HHS R01 HL098028NIBIB NIH HHS R01 EB027653
6 · The paper itself

Abstract

Visualizing viscoelastic waves in materials and tissues through noninvasive imaging is valuable for analyzing their mechanical properties and detecting internal anomalies. However, traditional elastography techniques have been limited by a maximum wave frequency below 1-10 kHz, which hampers temporal and spatial resolution. Here, we introduce an optical coherence elastography technique that overcomes the limitation by extending the frequency range to MHz. Our system can measure the stiffness of hard materials including bones and extract viscoelastic shear moduli for polymers and hydrogels in conventionally inaccessible ranges between 100 Hz and 1 MHz. The dispersion of Rayleigh surface waves across the ultrawide band allowed us to profile depth-dependent shear modulus in cartilages ex vivo and human skin in vivo with sub-mm anatomical resolution. This technique holds immense potential as a noninvasive measurement tool for material sciences, tissue engineering, and medical diagnostics.

Indexed as

Elasticity Imaging TechniquesGastropodaAcousticsAnimalsHumansHydrogelsUltrasonicsHydrogels

Identifiers

PMID37587178
PMCPMC10432526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.