Evidence map›Paper›PMID 37587903›Full record

ReviewGenes, brain, and behavior2023

The collaborative study on the genetics of alcoholism: Brain function.

Jacquelyn L Meyers, Sarah J Brislin, Chella Kamarajan, Martin H Plawecki, David Chorlian, Andrey Anohkin, Samuel Kuperman, Alison Merikangas, Gayathri Pandey, Sivan Kinreich and 6 more

Open access · hybridAbstract readReview
In one paragraph

Review in Genes, brain, and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Lifespan Trajectories of Resting State EEG power.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Childhood Trauma andmedRxiv : the preprint server for health sciences · 2025
    Article
  5. Pleiotropic Effects ofBiomolecules · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Sarah J BrislinDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0003-4303-8124
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Martin H PlaweckiDepartment of Psychiatry, Indiana University, Bloomington, Indiana, USA.
David ChorlianDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Andrey AnohkinDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.
Samuel KupermanDepartment of Psychiatry, University of Iowa, Iowa City, Indiana, USA.
Alison MerikangasDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-2253-839X
Gayathri PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Sivan KinreichDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Ashwini PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University, Bloomington, Indiana, USA.
Kathleen K BucholzDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-3794-0736
COGA Collaborators
Laura AlmasyDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
State University of New York · USChildren's Hospital of Philadelphia · USIndiana University Bloomington · USWashington University in St. Louis · USRutgers, The State University of New Jersey · USSUNY Downstate Health Sciences University · USUniversity of Iowa · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI Sarah Hartz · 1989 to 2026
$162.7M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U10AA008401NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

Alcohol use disorder (AUD) and related health conditions result from a complex interaction of genetic, neural and environmental factors, with differential impacts across the lifespan. From its inception, the Collaborative Study on the Genetics of Alcoholism (COGA) has focused on the importance of brain function as it relates to the risk and consequences of alcohol use and AUD, through the examination of noninvasively recorded brain electrical activity and neuropsychological tests. COGA's sophisticated neurophysiological and neuropsychological measures, together with rich longitudinal, multi-modal family data, have allowed us to disentangle brain-related risk and resilience factors from the consequences of prolonged and heavy alcohol use in the context of genomic and social-environmental influences over the lifespan. COGA has led the field in identifying genetic variation associated with brain functioning, which has advanced the understanding of how genomic risk affects AUD and related disorders. To date, the COGA study has amassed brain function data on over 9871 participants, 7837 with data at more than one time point, and with notable diversity in terms of age (from 7 to 97), gender (52% female), and self-reported race and ethnicity (28% Black, 9% Hispanic). These data are available to the research community through several mechanisms, including directly through the NIAAA, through dbGAP, and in collaboration with COGA investigators. In this review, we provide an overview of COGA's data collection methods and specific brain function measures assessed, and showcase the utility, significance, and contributions these data have made to our understanding of AUD and related disorders, highlighting COGA research findings.

Indexed as

AlcoholismAlcohol DrinkingBrainFemaleHumansMalealcohol use disorderEEGEROERPfamilygenomicsneurocognitiveneurodevelopmentneurophysiologyneuropsychological

Identifiers

PMID37587903
PMCPMC10550791
OpenAlexW4385897956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.