Evidence map›Paper›PMID 37588944›Full record

ArticleJournal of pharmacy and pharmacology research2023

Enhanced Cerebral Hemodynamics and Cognitive Function Via Knockout of Dual-Specificity Protein Phosphatase 5.

Huawei Zhang, Jane J Border, Xing Fang, Yedan Liu, Chengyun Tang, Wenjun Gao, Shaoxun Wang, Seung Min Shin, Ya Guo, Chao Zhang and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacy and pharmacology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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  3. Role ofbioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Huawei ZhangPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Jane J BorderPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Xing FangPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Yedan LiuPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Chengyun TangPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Wenjun GaoPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Shaoxun WangPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Seung Min ShinAnesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Ya GuoPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Chao ZhangPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Ezekiel Gonzalez-FernandezPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Hongwei YuAnesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Peng SunNeurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Richard J RomanPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Fan FanPharmacology &Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
University of Mississippi Medical Center · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVID E STEC · 2023 to 2026
$6.3M
Genetic determinants of hypertension-induced cerebral vascular dysfunctionR01HL138685 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2018 to 2021
$1.9M
Adducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2019 to 2023
$1.9M
Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRDRF1AG079336 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN, ROMAN, RICHARD J. · 2022 to 2022
$1.7M
Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRDR01AG079336 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI Fan Fan, Richard J. Roman · 2025 to 2026
$1.1M
NHLBI NIH HHS R01 HL138685NIA NIH HHS R01 AG057842NIA NIH HHS R01 AG079336NIA NIH HHS RF1 AG079336NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404
6 · The paper itself

Abstract

Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an early symptom of AD/ADRD. Dual-specificity protein phosphatase 5 (DUSP5) has been implicated in several pathological conditions, including pulmonary hypertension and cancer, but its role in AD/ADRD remains unclear. The present study builds on our previous findings, demonstrating that inhibition of ERK and PKC leads to a dose-dependent dilation of the middle cerebral artery and penetrating arteriole, with a more pronounced effect in

Indexed as

AD/ADRDcerebral hemodynamicsDusp5ERKPKC

Identifiers

PMID37588944
PMCPMC10430881
OpenAlexW4379185247

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.