Evidence map›Paper›PMID 37589055›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2023

Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial.

Abel Plaza-Florido, Irene Esteban-Cornejo, Jose Mora-Gonzalez, Lucia V Torres-Lopez, Francisco J Osuna-Prieto, Jose J Gil-Cosano, Shlomit Radom-Aizik, Idoia Labayen, Jonatan R Ruiz, Signe Altmäe and 1 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Abel Plaza-FloridoDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.ORCID 0000-0002-5374-3129
Irene Esteban-CornejoDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Jose Mora-GonzalezDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Lucia V Torres-LopezDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Francisco J Osuna-PrietoDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Jose J Gil-CosanoDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Shlomit Radom-AizikPediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California at Irvine, Irvine, California, United States.ORCID 0009-0004-4023-7026
Idoia LabayenCIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain.ORCID 0000-0002-4334-3287
Jonatan R RuizDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Signe AltmäeInstituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Francisco B OrtegaDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Universidad de Granada · ESKarolinska University Hospital · SEUniversidad Publica de Navarra · ESUniversity of California, Irvine · US

Funding

Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child HealthU01TR002004 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, RADOM-AIZIK, SHLOMIT · 2018 to 2022
$6.5M
NCATS NIH HHS U01 TR002004
6 · The paper itself

Abstract

We investigated the interaction between a genetic score and an exercise intervention on brain health in children with overweight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 yr, 59% girls) were randomized into a 20-wk combined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms [rs6265 (

Indexed as

Brain-Derived Neurotrophic FactorOverweightAdultApolipoproteins EBrainChildFemaleHumansMaleObesityApolipoproteins EBrain-Derived Neurotrophic Factorcognitionfitnessgeneticspediatricsphysical activity

Identifiers

PMID37589055
PMCPMC10642513
OpenAlexW4385897397

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.