Evidence mapPaperPMID 37589138Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y

Marta Brambilla, Alessia Becchetti, Gian Enrico Rovati, Nicola Cosentino, Maria Conti, Paola Canzano, Peter L A Giesen, Alessia Loffreda, Alice Bonomi, Marco Cattaneo and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Platelet reactivity to adenosine diphosphate andNeurosciences (Riyadh, Saudi Arabia) · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Marta BrambillaCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0002-7251-9106
Alessia BecchettiCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0003-4478-2123
Gian Enrico RovatiDepartment of Pharmaceutical Sciences (G.E.R., C.P., M. Camera), Università degli Studi di Milano, Italy.ORCID 0000-0002-8788-9783
Nicola CosentinoCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).
Maria ContiCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0002-7394-5190
Paola CanzanoCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).
Peter L A GiesenCoagScope BV, Maastricht, the Netherlands (P.L.A.G.).
Alessia LoffredaExperimental Imaging Center, San Raffaele Scientific Institute, Milan, Italy (A.L.).ORCID 0000-0003-4523-5666
Alice BonomiCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).
Marco CattaneoUnità di Medicina II, ASST Santi Paolo e Carlo, Department of Scienze della Salute (M. Cattaneo, G.M.P.), Università degli Studi di Milano, Italy.ORCID 0000-0002-7343-4534
Erica De CandiaDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy (E.D.C.).ORCID 0000-0003-0942-2819
Gian Marco PoddaUnità di Medicina II, ASST Santi Paolo e Carlo, Department of Scienze della Salute (M. Cattaneo, G.M.P.), Università degli Studi di Milano, Italy.ORCID 0000-0002-1791-8905
Daniela TrabattoniCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0002-6319-4119
Pablo Josè WerbaCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0001-7188-1157
Jeness CampodonicoCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0003-2276-9630
Christian PinnaDepartment of Pharmaceutical Sciences (G.E.R., C.P., M. Camera), Università degli Studi di Milano, Italy.ORCID 0000-0001-8701-1316
Giancarlo MarenziCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0003-4410-4461
Elena TremoliMaria Cecilia Hospital, Cotignola, Italy (E.T.).ORCID 0000-0003-3426-6424
Marina CameraCentro Cardiologico Monzino IRCCS, Milan, Italy (M.B., A. Becchetti, N.C., M. Conti, P.C., A. Bonomi, D.T., P.J.W., J.C., G.M., M. Camera).ORCID 0000-0002-7814-7067
Centro Cardiologico Monzino · ITUniversity of Milan · ITAOL (United States) · USMaastricht University · NLMaria Cecilia Hospital · ITUniversità Cattolica del Sacro Cuore · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundADP-induced platelet activation leads to cell surface expression of several proteins, including TF (tissue factor). The role of ADP receptors in platelet TF modulation is still unknown. We aimed to assess the (1) involvement of P2Y

methodsThe effects of P2Y

resultsIn blood from healthy subjects, stimulated in vitro by ADP, the percentage of TF

conclusionsData show that TF expression is regulated by P2Y

Indexed as

Coronary Artery DiseaseGray Platelet SyndromeBlood PlateletsClopidogrelHumansPlatelet AggregationPlatelet Aggregation InhibitorsPlatelet Function TestsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y12ThromboplastinTicagrelorClopidogrelP2RY12 protein, humanPlatelet Aggregation InhibitorsPrasugrel HydrochloridePurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y12ThromboplastinTicagrelorblood plateletscoronary artery diseaseP2Y12 antagonistsP2Y12 receptorthromboplastin

Identifiers

PMID37589138
PMCPMC10521789
OpenAlexW4385898209

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.