Evidence map›Paper›PMID 37589141›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes.

Madelynn N Whittaker, Lauren C Testa, Aidan Quigley, Ishaan Jindal, Saúl V Cortez-Alvarado, Ping Qu, Yifan Yang, Mohamad-Gabriel Alameh, Kiran Musunuru, Xiao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Clinical translation of epigenome editing technologies.Current opinion in biomedical engineering · 2026
    Article
  3. mRNA medicine for cardiovascular disease.Nature cardiovascular research · 2026
    Review
  4. Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026
    Review
  5. Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Hit-and-run epigenome editing durably lowers cholesterol in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  12. Methylation status ofEpigenomics · 2024
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Madelynn N WhittakerDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-3382-1134
Lauren C TestaDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Aidan QuigleyDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Ishaan JindalDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Saúl V Cortez-AlvaradoDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Ping QuDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Yifan YangDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Mohamad-Gabriel AlamehDivision of Infectious Diseases (M.-G.A.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-5672-6930
Kiran MusunuruDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-3298-0368
Xiao WangDivision of Cardiovascular Medicine and Cardiovascular Institute (M.N.W., L.C.T., A.Q., I.J., S.V.C.-A., P.Q., Y.Y., K.M., X.W.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-7502-8292

Funding

Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome EditingR35HL145203 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUSUNURU, KIRAN · 2019 to 2025
$5.7M
Physiological and therapeutic effects of ANGPTL3 variants in mice and humansR01HL148769 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CUCHEL, MARINA · 2019 to 2022
$3.0M
NHLBI NIH HHS R01 HL148769NHLBI NIH HHS R35 HL145203
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiovascular DiseasesEpigenomeCRISPR-Cas SystemsDNA MethylationEpigenesis, GeneticGene EditingHumanscardiovascular diseasescholesterolepigenomegene editinglipoprotein

Identifiers

PMID37589141
PMCPMC10538392

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.