Evidence map›Paper›PMID 37590134›Full record

ArticleCell reports2023

Role of Na

Carlos A da Silva, Cameron J Grover, Maria Cristina D Picardo, Christopher A Del Negro

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Article
  5. Interdependence of cellular and network properties in respiratory rhythm generation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carlos A da SilvaDepartment of Applied Science, William & Mary, Williamsburg, VA 23185, USA.
Cameron J GroverDepartment of Applied Science, William & Mary, Williamsburg, VA 23185, USA.
Maria Cristina D PicardoDepartment of Applied Science, William & Mary, Williamsburg, VA 23185, USA.
Christopher A Del NegroDepartment of Applied Science, William & Mary, Williamsburg, VA 23185, USA. Electronic address: cadeln@wm.edu.
William & Mary · US

Funding

Ion Channel Mechanisms of Inspiratory Breathing Movements in MiceR01NS107296 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2019 to 2022
$1.1M
The cellular and synaptic mechanisms of midbrain initiation of locomotion in mammalsR21NS114812 · NINDS · COLLEGE OF WILLIAM AND MARY · PI DEL NEGRO, CHRISTOPHER A. · 2020 to 2020
$397k
NINDS NIH HHS R01 NS107296NINDS NIH HHS R21 NS114812
6 · The paper itself

Abstract

Inspiration is the inexorable active phase of breathing. The brainstem pre-Bötzinger complex (preBötC) gives rise to inspiratory neural rhythm, but its underlying cellular and ionic bases remain unclear. The long-standing "pacemaker hypothesis" posits that the persistent Na

Indexed as

Brain StemRespirationAnimalsInterneuronsMiceNAV1.6 Voltage-Gated Sodium ChannelNeuronsRespiratory RateNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mousecentral pattern generatorCP: Neuroscienceeupneainspirationpersistent Na(+) currentpre-Bötzinger complexrespirationScn8a

Identifiers

PMID37590134
PMCPMC10528911
OpenAlexW4385879754

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.