Evidence map›Paper›PMID 37590419›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The mRNA stability factor Khd4 defines a specific mRNA regulon for membrane trafficking in the pathogen

Srimeenakshi Sankaranarayanan, Carl Haag, Patrick Petzsch, Karl Köhrer, Anna Matuszyńska, Kathi Zarnack, Michael Feldbrügge

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Puf4 -mediated oxidative stress virulence attenuation inFrontiers in cellular and infection microbiology · 2025
    Article
  4. Article
  5. Article
  6. The mRNA stability factor Khd4 defines a specific mRNA regulon for membrane trafficking in the pathogenProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Srimeenakshi SankaranarayananInstitute of Microbiology, Cluster of Excellence on Plant Sciences, Heinrich Heine University Düsseldorf, Düsseldorf 40204, Germany.ORCID 0000-0003-2146-0471
Carl HaagInstitute of Microbiology, Cluster of Excellence on Plant Sciences, Heinrich Heine University Düsseldorf, Düsseldorf 40204, Germany.
Patrick PetzschBiologisch-Medizinisches Forschungszentrum, Heinrich Heine University Düsseldorf, Düsseldorf 40204, Germany.ORCID 0000-0002-8355-5524
Karl KöhrerBiologisch-Medizinisches Forschungszentrum, Heinrich Heine University Düsseldorf, Düsseldorf 40204, Germany.
Anna MatuszyńskaDepartment of Biology, Computational Life Science, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen 52074, Germany.ORCID 0000-0003-0882-6088
Kathi ZarnackBuchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt a.M. 60438, Germany.ORCID 0000-0003-3527-3378
Michael FeldbrüggeInstitute of Microbiology, Cluster of Excellence on Plant Sciences, Heinrich Heine University Düsseldorf, Düsseldorf 40204, Germany.ORCID 0000-0003-0046-983X
Cluster of Excellence on Plant Sciences · DEHeinrich Heine University Düsseldorf · DEGoethe University Frankfurt · DERWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal pathogens depend on sophisticated gene expression programs for successful infection. A crucial component is RNA regulation mediated by RNA-binding proteins (RBPs). However, little is known about the spatiotemporal RNA control mechanisms during fungal pathogenicity. Here, we discover that the RBP Khd4 defines a distinct mRNA regulon to orchestrate membrane trafficking during pathogenic development of

Indexed as

RegulonRNA Stability3' Untranslated RegionsBasidiomycotaRNA, Messenger3' Untranslated RegionsRNA, Messengerfungal pathogenGTPasemembrane traffickingmRNA stabilitypolar growth

Identifiers

PMID37590419
PMCPMC10450656
OpenAlexW4385932278

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.