Evidence map›Paper›PMID 37591130›Full record

ReviewCurrent opinion in virology2023

Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines.

Rik L de Swart, George A Belov

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Progress in African Swine Fever Vector Vaccine Development.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Rik L de SwartDepartment of Virology, Wageningen Bioveterinary Research, Lelystad, the Netherlands. Electronic address: rik.deswart@wur.nl.
George A BelovDepartment of Veterinary Medicine and Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD, USA. Electronic address: gbelov@umd.edu.
University of Maryland, College Park · USWageningen University & Research · NL

Funding

Newcastle Disease Virus Vectored Vaccine against PoliomyelitisR21AI115383 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI BELOV, GEORGE A. · 2015 to 2016
$418k
Refocusing the immune response from structural to conserved non-structural proteins as a novel vaccination approach for inducing broad anti-enterovirus protectionR21AI153976 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI BELOV, GEORGE A. · 2020 to 2021
$418k
NIAID NIH HHS R21 AI115383NIAID NIH HHS R21 AI153976
6 · The paper itself

Abstract

Newcastle disease virus (NDV) is an avian pathogen with an unsegmented negative-strand RNA genome. Properties such as the ease of genome modification, respiratory tract tropism, and self-limiting replication in mammals make NDV an attractive vector for vaccine development. Experimental NDV-based vaccines against multiple human and animal pathogens elicited both systemic and mucosal immune responses and were protective in preclinical animal studies, but their real-life efficacy remains to be demonstrated. Only recently, the first results of clinical trials of NDV-based vaccines against SARS-CoV-2 became available, highlighting the challenges that need to be overcome to fully realize the potential of NDV as a platform for the rapid development of economically affordable and effective mucosal vaccines.

Indexed as

COVID-19Newcastle disease virusAnimalsCOVID-19 VaccinesHumansMammalsSARS-CoV-2COVID-19 Vaccines

Identifiers

PMID37591130
PMCPMC13262185
OpenAlexW4385846417

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.