Evidence map›Paper›PMID 37591865›Full record

ReviewNature reviews. Disease primers2023

HIV infection.

Linda-Gail Bekker, Chris Beyrer, Nyaradzo Mgodi, Sharon R Lewin, Sinead Delany-Moretlwe, Babafemi Taiwo, Mary Clare Masters, Jeffrey V Lazarus

Erratum issued Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06250881 (Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation), which is not on this map. Cited by 135 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06250881 unknown statusnot on this map

Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation

TypeobservationalSponsorZhongnan HospitalRan2023 to 2024Enrolled500ConditionsOcular Complications in AIDS Patients, Such as Fundus Opportunistic Infections, Microangiopathy, and Uveitis
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
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  14. NADThe Journal of general virology · 2026
    Review
  15. Article
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  17. Review
  18. Article
  19. Article
  20. HIV-1 Vif-dependent SUMOylation regulates viral RNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Linda-Gail BekkerThe Desmond Tutu HIV Centre, University of Cape Town, RSA, Cape Town, South Africa. Linda-Gail.Bekker@hiv-research.org.za.ORCID 0000-0002-0755-4386
Chris BeyrerDuke Global Health Institute, Duke University, Durham, NC, USA.
Nyaradzo MgodiUniversity of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe.ORCID 0000-0002-3085-5259
Sharon R LewinDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0002-0330-8241
Sinead Delany-MoretlweWits RHI, University of the Witwatersrand, Johannesburg, South Africa.
Babafemi TaiwoDivision of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Mary Clare MastersDivision of Infectious Diseases, Northwestern University, Chicago, IL, USA.
Jeffrey V LazarusCUNY Graduate School of Public Health and Health Policy, New York, NY, USA.ORCID 0000-0001-9618-2299

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
NIAID NIH HHS UM1 AI164560
6 · The paper itself

Abstract

The AIDS epidemic has been a global public health issue for more than 40 years and has resulted in ~40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted via body fluids and secretions. After infection, the virus invades host cells by attaching to CD4 receptors and thereafter one of two major chemokine coreceptors, CCR5 or CXCR4, destroying the host cell, most often a T lymphocyte, as it replicates. If unchecked this can lead to an immune-deficient state and demise over a period of ~2-10 years. The discovery and global roll-out of rapid diagnostics and effective antiretroviral therapy led to a large reduction in mortality and morbidity and to an expanding group of individuals requiring lifelong viral suppressive therapy. Viral suppression eliminates sexual transmission of the virus and greatly improves health outcomes. HIV infection, although still stigmatized, is now a chronic and manageable condition. Ultimate epidemic control will require prevention and treatment to be made available, affordable and accessible for all. Furthermore, the focus should be heavily oriented towards long-term well-being, care for multimorbidity and good quality of life. Intense research efforts continue for therapeutic and/or preventive vaccines, novel immunotherapies and a cure.

Indexed as

Acquired Immunodeficiency SyndromeEpidemicsHIV InfectionsHumansImmunotherapyQuality of Life

Identifiers

PMID37591865

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.