Evidence mapPaperPMID 37591977Full record

ArticleScientific reports2023

The DECON pilot project investigates predictive markers for successful bariatric surgery.

Gabriel Seifert, Luca Fagnocchi, Michael Edozie, Stephan Herrmann, Hannah Baumann, Ilaria Panzeri, Stephanie Mewes, David Aicher, Mira Runkel, Claudia Lässle and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gabriel SeifertDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany. gabriel.seifert@uniklinik-freiburg.de.
Luca FagnocchiVan Andel Institute, Grand Rapids, MI, 49503, USA.
Michael EdozieVan Andel Institute, Grand Rapids, MI, 49503, USA.
Stephan HerrmannDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Hannah BaumannDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Ilaria PanzeriVan Andel Institute, Grand Rapids, MI, 49503, USA.
Stephanie MewesDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
David AicherDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Mira RunkelDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Claudia LässleDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Jodok FinkDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Goran MarjanovicDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
Stephan Fichtner-FeiglDepartment of General and Visceral Surgery, University Medical Center Freiburg, University of Freiburg, Freiburg,, Germany.
J Andrew PospisilikVan Andel Institute, Grand Rapids, MI, 49503, USA. andrew.pospisilik@vai.org.

Funding

Master regulators of unexplained variation in disease riskR01HG012444 · VAN ANDEL RESEARCH INSTITUTE · 2025 to 2025
$1.9M
A Trim28-ERV axis drives phenotypic variation in obesityR01DK132216 · VAN ANDEL RESEARCH INSTITUTE · 2025 to 2025
$600k
NHGRI NIH HHS R01 HG012444NHGRI NIH HHS R21 HG011964NIDDK NIH HHS R01 DK132216
6 · The paper itself

Abstract

Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is one of the most effective treatments for individuals diagnosed with severe obesity. However, the current indications for bariatric surgery are based on inadequate metrics (i.e., BMI) which do not account for the complexity of the disease, nor the heterogeneity among the patient population. Moreover, there is a lack of understanding with respect to the biological underpinnings that influence successful and sustained weight loss post-bariatric surgery. Studies have implicated age and pre-surgery body weight as two factors that are associated with favorable patient outcomes. Still, there is an urgent medical need to identify other potential factors that could improve the specificity of candidate selection and better inform the treatment plan of patients with obesity. In this report, we present and describe the cohort of the DECON pilot project, a multicenter study which aims to identify predictive biomarkers of successful weight loss after bariatric surgery.

Indexed as

Bariatric SurgeryObesity, MorbidHumansObesityPilot ProjectsWeight Loss

Identifiers

PMID37591977
PMCPMC10435485

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.