Evidence map›Paper›PMID 37592253›Full record

ArticleBMC veterinary research2023

The MARS PETCARE BIOBANK protocol: establishing a longitudinal study of health and disease in dogs and cats.

Janet E Alexander, Serina Filler, Philip J Bergman, Claire E Bowring, Laura Carvell-Miller, Brenda Fulcher, Richard Haydock, Teresa Lightfoot, Darren W Logan, Talon S McKee and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Janet E AlexanderWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK. Janet.Alexander@effem.com.ORCID http://orcid.org/0000-0002-1028-4022
Serina FillerWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Philip J BergmanVCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, CA, USA.
Claire E BowringWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Laura Carvell-MillerWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Brenda FulcherBluePearl Science, 2950 Busch Lake Blvd, Tampa, FL, USA.
Richard HaydockWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Teresa LightfootBluePearl Science, 2950 Busch Lake Blvd, Tampa, FL, USA.
Darren W LoganWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Talon S McKeeVCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, CA, USA.
Tracy MillsVCA Clinical Studies, 12401 West Olympic Blvd, Los Angeles, CA, USA.
JoAnn MorrisonBanfield Pet Hospital, 18101 SE 6Th Way, Vancouver, WA, USA.
Phillip WatsonWaltham Petcare Science Institute, Waltham On the Wolds, Leicestershire, UK.
Colby WoodruffAntech Diagnostics, 17620 Mount Herrmann St, Fountain Valley, CA, USA.
Mars Petcare Biobank Project Team
Clinical Research Associates · USAstraZeneca (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe veterinary care of cats and dogs is increasingly embracing innovations first applied to human health, including an increased emphasis on preventative care and precision medicine. Large scale human population biobanks have advanced research in these areas; however, few have been established in veterinary medicine. The MARS PETCARE BIOBANK™ (MPB) is a prospective study that aims to build a longitudinal bank of biological samples, with paired medical and lifestyle data, from 20,000 initially healthy cats and dogs (10,000 / species), recruited through veterinary hospitals over a ten-year period. Here, we describe the MPB protocol and discuss its potential as a platform to increase understanding of why and how diseases develop and how to advance personalised veterinary healthcare.

methodsAt regular intervals, extensive diet, health and lifestyle information, electronic medical records, clinicopathology and activity data are collected, genotypes, whole genome sequences and faecal metagenomes analysed, and blood, plasma, serum, and faecal samples stored for future research. DISCUSSION: Proposed areas for research include the early detection and progression of age-related disease, risk factors for common conditions, the influence of the microbiome on health and disease and, through genome wide association studies, the identification of candidate loci for disease associated genetic variants. Genomic data will be open access and research proposals for access to data and samples will be considered. Over the coming years, the MPB will provide the longitudinal data and systematically collected biological samples required to generate important insights into companion animal health, identifying biomarkers of disease, supporting earlier identification of risk, and enabling individually tailored interventions to manage disease.

Indexed as

Cat DiseasesDog DiseasesAnimalsBiological Specimen BanksCatsDogsGenome-Wide Association StudyHumansLongitudinal StudiesProspective StudiesBiomarkerCanineCohortDiseaseFelineGenomicLongitudinalMicrobiomeProspectiveRepositoryRisk factors

Identifiers

PMID37592253
PMCPMC10433631
OpenAlexW4385913125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.