Evidence map›Paper›PMID 37595342›Full record

ReviewCurrent opinion in cell biology2023

Mechanosensitive GPCRs and ion channels in shear stress sensing.

Rui Xiao, Jie Liu, X Z Shawn Xu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  7. Article
  8. Review
  9. GABA-independent activation of GABANature communications · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Mechanotransduction in the Perivascular Adipose Tissue.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Shear stress sensing in C. elegans.Current biology : CB · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Rui XiaoDepartment of Physiology and Aging, Institute on Aging, Center for Smell and Taste, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: rxiao@ufl.edu.
Jie LiuNeuroscience Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
X Z Shawn XuLife Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: shawnxu@umich.edu.
Monash University · AUUniversity of Florida · USUniversity of Michigan · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Neural circuits and synaptic mechanisms underlying behavior in C. elegansR01GM083241 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2008 to 2017
$3.4M
Neural and genetic mechanisms underlying behavior in C. elegans - Administrative Supplement for Equipment PurchasesR35GM126917 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2018 to 2025
$3.3M
An unexpected role of glutamate receptors in the peripheral nervous systemR01NS118769 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO, XU, SHAWN · 2020 to 2024
$2.6M
Neural and genetic mechanisms underlying mechanosensation in C. elegansR01DC018167 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2020 to 2025
$2.3M
Dissecting the mechanisms of Alzheimer's disease (AD)-related smell loss in a C. elegans AD modelR01AG063766 · NIA · UNIVERSITY OF FLORIDA · PI XIAO, RUI · 2019 to 2023
$1.9M
Chemosensation and longevity in C. elegansR01AG067753 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, SHAWN · 2020 to 2024
$1.8M
NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG063766NIA NIH HHS R01 AG067753NIDCD NIH HHS R01 DC018167NIGMS NIH HHS R01 GM083241NIGMS NIH HHS R35 GM126917NINDS NIH HHS R01 NS118769
6 · The paper itself

Abstract

As a universal mechanical cue, shear stress plays essential roles in many physiological processes, ranging from vascular morphogenesis and remodeling to renal transport and airway barrier function. Disrupted shear stress is commonly regarded as a major contributor to various human diseases such as atherosclerosis, hypertension, and chronic kidney disease. Despite the importance of shear stress in physiology and pathophysiology, our current understanding of mechanosensors that sense shear stress is far from complete. An increasing number of candidate mechanosensors have been proposed to mediate shear stress sensing in distinct cell types, including G protein-coupled receptors (GPCRs), G proteins, receptor tyrosine kinases, ion channels, glycocalyx proteins, and junctional proteins. Although multiple types of mechanosensors might be able to convert shear stress into downstream biochemical signaling events, in this review, we will focus on discussing the mechanosensitive GPCRs (angiotensin II type 1 receptor, GPR68, histamine H1 receptor, adhesion GPCRs) and ion channels (Piezo, TRP) that have been reported to be directly activated by shear stress.

Indexed as

Receptor Protein-Tyrosine KinasesSignal TransductionHumansReceptors, G-Protein-CoupledGPR68 protein, humanReceptor Protein-Tyrosine KinasesReceptors, G-Protein-Coupled

Identifiers

PMID37595342
PMCPMC10528224
OpenAlexW4385888791

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.