ArticleScientific reports2023
Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- 2025 FelineVMA feline oral health and dental care guidelines.Journal of feline medicine and surgery · 2025Guideline
- Alterations in the feline oral microbiome in common oral diseases - A comprehensive review.European journal of microbiology & immunology · 2026Review
- The Biodistribution ofVeterinary sciences · 2026Article
- Serum peptidomic profiling identifies systemic JAK-STAT and PI3K-Akt pathway dysregulation in cats with chronic gingivostomatitis.Journal of veterinary internal medicine · 2026Article
- Unilateral partial-mouth extraction achieves complete clinical remission in cats with unilateral caudal feline chronic gingivostomatitis: a case series.BMC veterinary research · 2026Article
- Construction of Reverse Genetics System for Feline Calicivirus FCV-BJ616 and Proteomic Analysis.MicrobiologyOpen · 2026Article
- Comparison of simple and rapid collection methods for measuring salivary IL-6 and PGEBrazilian journal of veterinary medicine · 2026Article
- Long-term efficacy of cyclosporine and interferon-ω in feline chronic gingivostomatitis: insights from SDAI scores.BMC veterinary research · 2025Article
- Transcriptomes of thirteen healthy feline tissue types.BMC genomics · 2025Article
- Efficacy and safety of omega-3-enriched lickable treats as adjunctive therapy for feline chronic gingivostomatitis: A randomized controlled trial.Veterinary world · 2025Article
- Impact of pro-inflammatory cytokine preconditioning on metabolism and extracellular vesicles in feline mesenchymal stromal cells: a preliminary study.Stem cells (Dayton, Ohio) · 2025Article
- Case Report: Shift from Aggressive Periodontitis to Feline Chronic Gingivostomatitis Is Linked to Increased Microbial Diversity.Pathogens (Basel, Switzerland) · 2025Article
- Clinical and histopathological investigation of the possible occurrence of tracheobronchial disease in cats with chronic gingivostomatitis.Frontiers in veterinary science · 2025Article
- Local and systemic immunological response in feline chronic gingivostomatitis: a critical review.Frontiers in immunology · 2025Review
- Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights.Pathogens (Basel, Switzerland) · 2024Article
- The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats.Animals : an open access journal from MDPI · 2023Article
- Feline chronic gingivostomatitis current concepts in clinical management.Journal of feline medicine and surgery · 2023Review
- Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and nanoscale liquid chromatography-tandem mass spectrometry.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation and ulceration of the caudal oral mucosa, alveolar and buccal mucosa, and varying degrees of periodontal disease. The etiopathogenesis of FCGS remains unresolved. In this study, we performed bulk RNA-seq molecular profiling of affected tissues derived from a cohort of client-owned cats with FCGS compared to tissues from unaffected animals, to identify candidate genes and pathways that can help guide future exploration of novel clinical solutions. We complemented transcriptomic findings with immunohistochemistry and in situ hybridization assays to better understand the biological significance of the results and performed RNA-seq validation of biologically relevant differentially expressed genes using qPCR assays to demonstrate technical reproducibility. Transcriptomic profiles of oral mucosal tissues in cats with FCGS are enriched with immune- and inflammation-related genes and pathways that appear to be largely influenced by IL6, and include NFKB, JAK/STAT, IL-17 and IFN type I and II signaling, offering new opportunities to develop novel clinical applications based on a more rational understanding of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.