Evidence map›Paper›PMID 37596741›Full record

ArticleInternational journal of immunopathology and pharmacology

Changes in serum hypoxia-inducible factor-1α and erythropoietin in allergic rhinitis patients: Correlation with the Th inflammatory profile and disease comorbidities.

Abdullah N Al-Rasheedi, Abdulrahman H Almaeen, Abdullah D Alotaibi, Abdulaziz S D Alruwaili, Sultan H H Alruwaili, Wadad M A Alruwaili, Aljoharah S Alsakhry, Ghuyudh M Alruwaili, Hala M ALkuwaykibi, Noof N Alrawili and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Abdullah N Al-RasheediDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Abdulrahman H AlmaeenDepartment of Pathology, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Abdullah D AlotaibiDepartment of Otolaryngology, College of Medicine, University of Hail, Hail, Saudi Arabia.
Abdulaziz S D AlruwailiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Sultan H H AlruwailiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Wadad M A AlruwailiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Aljoharah S AlsakhryCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Ghuyudh M AlruwailiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Hala M ALkuwaykibiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Noof N AlrawiliCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Rahaf Z AlabdullahCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Reem S AlatwiCollege of Medicine, Jouf University, Sakaka, Saudi Arabia.
Ibrahim TaherDepartment of Pathology, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Tarek H El-MetwallyDepartment of Pathology, College of Medicine, Jouf University, Sakaka, Saudi Arabia.ORCID 0000-0001-9040-6642
Jouf University · SAUniversity of Ha'il · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe balance between proinflammatory IFN-γ Th1 vs. the anti-inflammatory allergy-mediating IL-4-heralded Th2 reactions is pivotal in IgE-mediated allergic rhinitis (AR). Hypoxia-Inducible Factor (HIF)-1α is inducible by hypoxia and various cytokines. HIF-1α activates different anti-pathogen and allergic immune cells. This cross-sectional study assessed the changes in serum HIF-1α and its dependent erythropoietin (EPO) levels among hospital-characterized AR patients. Type of the immune reaction, Th1 vs. Th2, was stratified based on the calculated IL-4/IFN-γ direct ratio, after being measured using specific ELISA assays.

methods147 AR patients (83 males/64 females), and age-, BMI-, and gender-matched 24 healthy controls (13 males/11 females) were sequentially enrolled at ENT Unit, Prince Muteb General Hospital, Sakaka, Saudi Arabia. Measurement of serum parameters was carried out using specific ELISA assays.

resultsContrary to the majority of previous publications, all controls and the majority of patients (

conclusionThese results confirmed a pathogenic implication for HIF-1α and IFN-γ in AR that warranted future bigger and longitudinal studies.

Indexed as

ErythropoietinRhinitis, AllergicCross-Sectional StudiesFemaleHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInterleukin-4MaleEPO protein, humanErythropoietinHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInterleukin-4allergic rhinitiserythropoietinhypoxia-inducible factor-1αIFN-γIL-4IL-4/IFN-γ ratio

Identifiers

PMID37596741
PMCPMC10440105
OpenAlexW4385997424

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.