Evidence map›Paper›PMID 37596837›Full record

ArticleThe Journal of infectious diseases2023

Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting.

Armand Sprecher, Robert Cross, Andrea Marzi, Karen A Martins, Daniel Wolfe, Joel M Montgomery, Christina F Spiropoulou, Tomas Cihlar, Steve Ahuka-Mundeke, Tara Nyhuis and 8 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 4 countries.

Armand SprecherMédecins Sans Frontières, Brussels, Belgium.
Robert CrossGalveston National Laboratory, University of Texas Medical Branch, Galveston.
Andrea MarziLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.ORCID 0000-0003-0186-9587
Karen A MartinsBiomedical Advanced Research and Development Authority, Administration for Strategic Preparedness and Response, US Department of Health and Human Services, Washington, District of Columbia.
Daniel WolfeBiomedical Advanced Research and Development Authority, Administration for Strategic Preparedness and Response, US Department of Health and Human Services, Washington, District of Columbia.
Joel M MontgomeryViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.ORCID 0000-0003-0523-4431
Christina F SpiropoulouViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Tomas CihlarGilead Sciences Inc, Foster City, California.
Steve Ahuka-MundekeInstitut National de Recherche Biomédicale, Kinshasa, Republic of the Congo.
Tara NyhuisMapp Biopharmaceutical, Inc, San Diego, California.
Carrie TeicherMédecins Sans Frontières, New York, New York.
Ian CrozierClinical Monitoring Program Research Directorate, Frederick National Laboratory for Cancer Research, Maryland.
Jim StrongSpecial Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada.
Gary KobingerGalveston National Laboratory, University of Texas Medical Branch, Galveston.
Courtney WoolseyGalveston National Laboratory, University of Texas Medical Branch, Galveston.
Thomas W GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston.
Heinz FeldmannLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.ORCID 0000-0001-9448-8227
Jean-Jacques MuyembeInstitut National de Recherche Biomédicale, Kinshasa, Republic of the Congo.
The University of Texas Medical Branch at Galveston · USBiomedical Advanced Research and Development Authority · USCenters for Disease Control and Prevention · USNational Institutes of Health · USUniversity of Kinshasa · CDFrederick National Laboratory for Cancer Research · USGilead Sciences (United States) · USMapp Biopharmaceutical (United States) · USMédecins Sans Frontières · BEMédecins Sans Frontières · USPublic Health Agency of Canada · CA

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Although there are now approved treatments and vaccines for Ebola virus disease, the case fatality rate remains unacceptably high even when patients are treated with the newly approved therapeutics. Furthermore, these countermeasures are not expected to be effective against disease caused by other filoviruses. A meeting of subject-matter experts was held during the 10th International Filovirus Symposium to discuss strategies to address these gaps. Several investigational therapeutics, vaccine candidates, and combination strategies were presented. The greatest challenge was identified to be the implementation of well-designed clinical trials of safety and efficacy during filovirus disease outbreaks. Preparing for this will require agreed-upon common protocols for trials intended to bridge multiple outbreaks across all at-risk countries. A multinational research consortium including at-risk countries would be an ideal mechanism to negotiate agreement on protocol design and coordinate preparation. Discussion participants recommended a follow-up meeting be held in Africa to establish such a consortium.

Indexed as

EbolavirusFiloviridaeFiloviridae InfectionsHemorrhagic Fever, EbolaAfricaDisease OutbreaksHumansclinical trialsdisease outbreaksfilovirusestherapeuticsvaccines

Identifiers

PMID37596837
PMCPMC10651188
OpenAlexW4385997280

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.