Evidence map›Paper›PMID 37598162›Full record

ArticleJournal of nanobiotechnology2023

Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation.

Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li, Hao Chen, Lizeng Gao

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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  11. Electron-injected Pd@CeOJournal of nanobiotechnology · 2025
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  12. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhuobin Xu *Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Yufei Zhu *Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Mengke XieInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Kankan LiuInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Liangliang CaiInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Huihui WangInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China.
Dandan LiInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China. 006544@yzu.edu.cn.
Hao ChenInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225009, China. hchen2020@yzu.edu.cn.
Lizeng GaoCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. gaolizeng@ibp.ac.cn.
Yangzhou University · CNInstitute of Biophysics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron sulfide nanomaterials have been successfully employed as therapeutic agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due to their unique structures, physiochemical properties, and biocompatibility. However, biomedical research and understanding of the biological functions of iron sulfides are insufficient, and how iron sulfide nanomaterials affect reactive oxygen species (ROS) in diseases remains unknown. Acute kidney injury (AKI) is associated with high levels of ROS, and therefore nanomedicine-mediated antioxidant therapy has emerged as a novel strategy for its alleviation.

resultsHere, mackinawite nanozymes were synthesized from glutathione (GSH) and iron ions (Fe

conclusionsGiven the synergetic antioxidant properties and high biocompatibility, GFeSNs exhibit great potential for the treatment of AKI and other ROS-associated diseases.

Indexed as

Acute Kidney InjuryAntioxidantsAnimalsFerrous CompoundsFishesGlutathioneIronReactive Oxygen SpeciesAntioxidantsFerrous Compoundsferrous sulfideGlutathioneIronReactive Oxygen SpeciesAcute kidney injuryIron sulfidesMackinawite nanozymesReactive oxygen species

Identifiers

PMID37598162
PMCPMC10439570
OpenAlexW4386001222

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.