Evidence map›Paper›PMID 37604195›Full record

ArticleJournal of neurological surgery. Part A, Central European neurosurgery2024

The LRG-TGF-β-Alk-1/TGFßRII-Smads as Predictive Biomarkers of Chronic Hydrocephalus after Aneurysmal Subarachnoid Hemorrhage.

Dongying Ma, Luyao Ma, Yongqiang Zhao, Yongli Li, Wei Ye, Xianfeng Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurological surgery. Part A, Central European neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dongying MaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Luyao MaDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongqiang ZhaoDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongli LiDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei YeDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xianfeng LiDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH); however, the risk factors and the mechanisms underlying its occurrence have yet to be fully elucidated. The purpose of this study was to identify biomarkers that could be used to predict chronic hydrocephalus after aSAH and to investigate the relationships.

methodsWe analyzed cerebrospinal fluid (CSF) samples from 19 patients with chronic hydrocephalus after aSAH and 44 controls without hydrocephalus after aSAH. Enzyme-linked immunosorbent assay was used to determine the levels of leucine-rich alpha-2-glycoprotein (LRG), transforming growth factor-β (TGF-β), Smad1, Smad4, Smad5, Smad8, activin receptor-like kinase 1 (Alk-1), activin receptor-like kinase 5 (Alk-5), P38, and TGF-β type II receptor (TGFßRII) in CSF samples.

resultsIn the CSF of patients with chronic hydrocephalus after aSAH, the levels of LRG, TGF-β, Alk-1, Smad5, and TGFßRII were significantly increased (

conclusionThe levels of LRG, TGF-β, Alk-1, TGFßRII, Smad1/5/8, and Smad4 in the CSF are potentially helpful as predictive biomarkers of chronic hydrocephalus after aSAH. Moreover, the LRG-TGF-β-Alk-1/TGFßRII-Smad1/5/8-Smad4 signaling pathway is highly likely to be involved in the pathogenic process of chronic hydrocephalus after aSAH.

Indexed as

BiomarkersHydrocephalusReceptor, Transforming Growth Factor-beta Type IISubarachnoid HemorrhageTransforming Growth Factor betaActivin Receptors, Type IActivin Receptors, Type IIAdultAgedChronic DiseaseFemaleGlycoproteinsHumansMaleMiddle AgedReceptors, Transforming Growth Factor betaActivin Receptors, Type IActivin Receptors, Type IIACVRL1 protein, humanBiomarkersGlycoproteinsLRG1 protein, humanReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IISmad ProteinsTGFBR2 protein, humanTransforming Growth Factor beta

Identifiers

PMID37604195
PMCPMC11281838
OpenAlexW4386023407

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.