Evidence map›Paper›PMID 37604306›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2023

Viruses and Human Milk: Transmission or Protection?

Rachele Francese, Chiara Peila, Manuela Donalisio, Cristina Lamberti, Simona Cirrincione, Nicoletta Colombi, Paola Tonetto, Laura Cavallarin, Enrico Bertino, Guido E Moro and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Exploring human milk donation: A cross-sectional study.Public health in practice (Oxford, England) · 2026
    Article
  5. Article
  6. A Framework for Evaluation of New Processing Technologies in Human Milk Banking.Comprehensive reviews in food science and food safety · 2025
    Review
  7. Deliberating the scientific evidence base for influenza transmission to raw milk consumers.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rachele FranceseDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, Orbassano (TO), Italy.
Chiara PeilaDepartment of Public Health and Pediatrics, Neonatal Intensive Care Unit, University of Turin, Turin, Italy.
Manuela DonalisioDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, Orbassano (TO), Italy.
Cristina LambertiInstitute of the Science of Food Production - National Research Council, Grugliasco, TO, Italy.
Simona CirrincioneInstitute of the Science of Food Production - National Research Council, Grugliasco, TO, Italy.
Nicoletta ColombiBiblioteca Federata di Medicina "Ferdinando Rossi", University of Turin, Turin, Italy.
Paola TonettoDepartment of Public Health and Pediatrics, Neonatal Intensive Care Unit, University of Turin, Turin, Italy.
Laura CavallarinInstitute of the Science of Food Production - National Research Council, Grugliasco, TO, Italy.
Enrico BertinoDepartment of Public Health and Pediatrics, Neonatal Intensive Care Unit, University of Turin, Turin, Italy.
Guido E MoroItalian Association of Human Milk Banks (AIBLUD), Milan, Italy. Electronic address: guidoemoro@tiscali.it.
Alessandra CosciaDepartment of Public Health and Pediatrics, Neonatal Intensive Care Unit, University of Turin, Turin, Italy. Electronic address: alessandra.coscia@unito.it.
David LemboDepartment of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, Orbassano (TO), Italy. Electronic address: david.lembo@unito.it.
University of Turin · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk (HM) is considered the best source of nutrition for infant growth and health. This nourishment is unique and changes constantly during lactation to adapt to the physiological needs of the developing infant. It is also recognized as a potential route of transmission of some viral pathogens although the presence of a virus in HM rarely leads to a disease in an infant. This intriguing paradox can be explained by considering the intrinsic antiviral properties of HM. In this comprehensive and schematically presented review, we have described what viruses have been detected in HM so far and what their potential transmission risk through breastfeeding is. We have provided a description of all the antiviral compounds of HM, along with an analysis of their demonstrated and hypothesized mechanisms of action. Finally, we have also analyzed the impact of HM pasteurization and storage methods on the detection and transmission of viruses, and on the antiviral compounds of HM. We have highlighted that there is currently a deep knowledge on the potential transmission of viral pathogens through breastfeeding and on the antiviral properties of HM. The current evidence suggests that, in most cases, it is unnecessarily to deprive an infant of this high-quality nourishment and that the continuation of breastfeeding is in the best interest of the infant and the mother.

Indexed as

Milk, HumanVirusesAntiviral AgentsBreast FeedingFemaleHumansInfantLactationAntiviral Agentsantiviral activityhuman milkmother-to-child transmissionpasteurizationvirus detection

Identifiers

PMID37604306
PMCPMC10721544
OpenAlexW4386012830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.