Evidence map›Paper›PMID 37608673›Full record

ArticleCurrent computer-aided drug design2024

Neng Tine Kartinah, Suci Anggraini, Fadilah Fadilah, Rickie Rickie

Abstract read
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In one paragraph

Article in Current computer-aided drug design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neng Tine KartinahDepartement of Medical Physiology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia.
Suci AnggrainiMaster's Programme in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia.
Fadilah FadilahDepartment of Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia.
Rickie RickieMaster's Programme in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia.
University of Indonesia · ID

Funding

Hibah Publikasi Terindeks Internasional Sain Teknologi dan Kesehatan (PUTI Saintekes) Universitas Indonesia NKB-1547/UN2.R3.1/HKP.05.00/2019
6 · The paper itself

Abstract

backgroundLeptin is predominant in regulating body weight by stimulating energy expenditure through its neuronal action in the brain. Moreover, it is projected to adipose tissue and induces adipocyte browning by activating the β3-adrenergic receptor (β3AR). However, the expression of leptin receptor (Lep-R) and β3AR in people with obesity is downregulated.

aimWe hypothesized that

methodsTwenty-four male

resultsHSE administration significantly (p <0,05) increased the ARC Lep-R expression. The Lee index significantly decreased to the normal range (≤ 310) with p <0,001 for DIO-Hib200 and p <0,01 for DIO-Hib400. Among 39 bioactive compounds,

conclusionThis study highlights that HSE could be a potential therapeutic target for obesity by increasing LepR mRNA and leptin sensitivity, enhancing energy expenditure, and reducing obesity.

Indexed as

Anti-Obesity AgentsArcuate Nucleus of HypothalamusHibiscusObesityPlant ExtractsRats, Sprague-DawleyReceptors, LeptinRNA, MessengerAnimalsComputer SimulationDiet, High-FatMaleMolecular Docking SimulationRatsAnti-Obesity AgentsPlant ExtractsReceptors, LeptinRNA, Messengeradipocyte browningdocking protein simulationHibiscus sabdariffa.high-fat dietleptin resistanceObesity

Identifiers

PMID37608673
OpenAlexW4386083684

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.