ArticleChild development
Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex.
Francheska M Merced-Nieves, Samuel Eitenbichler, Brandon Goldson, Xueying Zhang, Daniel N Klein, Michelle Bosquet Enlow, Paul Curtin, Robert O Wright, Rosalind J Wright
Open access · bronzeAbstract read
In one paragraphArticle in Child development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 1 country.
Francheska M Merced-NievesDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0947-4029 Samuel EitenbichlerIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Brandon GoldsonIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Xueying ZhangDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Daniel N KleinDepartment of Psychology, Stony Brook University, Stony Brook, New York, USA.
Michelle Bosquet EnlowDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
Paul CurtinDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert O WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Rosalind J WrightDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USBoston Children's Hospital · USStony Brook University · US
Funding
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1MConduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MThe Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3MMount Sinai ECHO site for Perinatal Environment and Development StudiesUG3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARROLL, KECIA NICOLE, WRIGHT, ROBERT O · 2016 to 2024
$20.6MResearch Training Program in Pediatric ExposomicsT32HD049311 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2007 to 2026
$7.4MJ: NRSA Training CoreTL1TR004420 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JANICE L GABRILOVE, Robert O Wright · 2022 to 2026
$3.9MPrenatal metal mixtures and neurodevelopment: Role of placental extracellular microRNAsR01ES030302 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LU, QUAN, WRIGHT, ROSALIND J · 2019 to 2023
$3.2MPrenatal metal-stress mixtures and transdiagnostic pathways to preadolescent internalizing disorders: Role of placental molecular signalingR01ES033436 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2021 to 2025
$2.9MNCATS NIH HHS TL1 TR004420NCATS NIH HHS UL1 TR004419NICHD NIH HHS T32 HD049311NIEHS NIH HHS P30 ES023515NIEHS NIH HHS P30ES023515NIEHS NIH HHS R01 ES030302NIEHS NIH HHS R01ES030302NIEHS NIH HHS R01 ES033436NIEHS NIH HHS R01ES033436NIH HHS UG3 OD023337NIH HHS UH3 OD023337
6 · The paper itselfAbstract
In-utero exposures interact in complex ways that influence neurodevelopment. Animal research demonstrates that fetal sex moderates the impact of joint exposure to metals and prenatal stress measures, including cortisol, on offspring socioemotional outcomes. Further research is needed in humans. We evaluated the joint association of prenatal exposures to a metal mixture and cortisol with infant negative affectivity, considering sex differences. Analyses included 226 (29% White, Non-Hispanic) mother-infant pairs with data on exposures and negative affectivity assessed using the Infant Behavior Questionnaire-Revised in 6-month-olds. Results showed that girls whose mothers had higher cortisol had significantly higher scores of Fear and Sadness with greater exposure to the mixture. Examining higher-order interactions may better elucidate the effects of prenatal exposure to metals and cortisol on socioemotional functioning.
Indexed as
HydrocortisonePrenatal Exposure Delayed EffectsFearFemaleHumansInfantMaleMothersPregnancyStress, PsychologicalSurveys and QuestionnairesHydrocortisone
Identifiers
PMID37610319
PMCPMC10840921
OpenAlexW4386084624
What Socratic holds
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