Evidence map›Paper›PMID 37612482›Full record

ArticleTranslational stroke research2024

A Transcriptomic Comparative Study of Cranial Vasculature.

Jianing Zhang, Jee-Yeon Ryu, Selena-Rae Tirado, Lawrence D Dickinson, Aviva Abosch, M Ali Aziz-Sultan, Alan S Boulos, Daniel L Barrow, H Hunt Batjer, Tamar R Binyamin and 24 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 14 institutions in 3 countries.

Jianing ZhangDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Jee-Yeon RyuDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Selena-Rae TiradoDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Lawrence D DickinsonDepartment of Neurosurgery, Sutter Health, Danville, CA, USA.
Aviva AboschDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USA.
M Ali Aziz-SultanDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Alan S BoulosDepartment of Neurosurgery, Albany Medical Center, Albany, NY, USA.
Daniel L BarrowDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
H Hunt BatjerDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, USA.
Tamar R BinyaminDepartment of Neurosurgery, Sutter Health, Danville, CA, USA.
Spiros L BlackburnDepartment of Neurosurgery, University of Texas Health Science Center, Houston, TX, USA.
Edward F ChangDepartment of Neurosurgery, University of California San Francisco, San Francisco, CA, USA.
P Roc ChenDepartment of Neurosurgery, University of Texas Health Science Center, Houston, TX, USA.
Geoffrey P ColbyDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.
G Rees CosgroveDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Carlos A DavidDepartment of Neurosurgery, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
Arthur L DayDepartment of Neurosurgery, University of Texas Health Science Center, Houston, TX, USA.
Rebecca D FolkerthDepartment of Forensic Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Kai U FrerichsDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Brian M HowardDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Behnam R JahromiDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Mika NiemelaDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Steven G OjemannDepartment of Neurosurgery, University of Colorado, Denver, CO, USA.
Nirav J PatelDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
R Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Xiangen ShiDepartment of Neurosurgery, Affiliated Fuxing Hospital, Capital Medical University, Beijing, China.
Edison P Valle-GilerDepartment of Neurosurgery, NCH Baker Hospital, Naples, FL, USA.
Anthony C WangDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.
Babu G WelchDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, USA.
Ziv WilliamsDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Edie E ZusmanNeuroscience Partners, Moraga, Oakland, CA, USA.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rose DuDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. rdu@bwh.harvard.edu.
GENIE Investigators
Brigham and Women's Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of California, Los Angeles · USEmory University · USHelsinki University Hospital · FIMassachusetts General Hospital · USSutter Health · USThe University of Texas Southwestern Medical Center · USAlbany Medical Center Hospital · USCapital Medical University · CNNew York University · USUniversity of Colorado Denver · USUniversity of Nebraska Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Systems Genetics Approach to Intracranial AneurysmsR01NS105675 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI DU, ROSE · 2019 to 2023
$3.7M
NIH HHS 1R01 NS105675NINDS NIH HHS R01 NS105675
6 · The paper itself

Abstract

In genetic studies of cerebrovascular diseases, the optimal vessels to use as controls remain unclear. Our goal is to compare the transcriptomic profiles among 3 different types of control vessels: superficial temporal artery (STA), middle cerebral arteries (MCA), and arteries from the circle of Willis obtained from autopsies (AU). We examined the transcriptomic profiles of STA, MCA, and AU using RNAseq. We also investigated the effects of using these control groups on the results of the comparisons between aneurysms and the control arteries. Our study showed that when comparing pathological cerebral arteries to control groups, all control groups presented similar responses in the activation of immunological processes, the regulation of intracellular signaling pathways, and extracellular matrix productions, despite their intrinsic biological differences. When compared to STA, AU exhibited upregulation of stress and apoptosis genes, whereas MCA showed upregulation of genes associated with tRNA/rRNA processing. Moreover, our results suggest that the matched case-control study design, which involves control STA samples collected from the same subjects of matched aneurysm samples in our study, can improve the identification of non-inherited disease-associated genes. Given the challenges associated with obtaining fresh intracranial arteries from healthy individuals, our study suggests that using MCA, AU, or paired STA samples as controls are feasible strategies for future large-scale studies investigating cerebral vasculopathies. However, the intrinsic differences of each type of control should be taken into consideration when interpreting the results. With the limitations of each control type, it may be most optimal to use multiple tissues as controls.

Indexed as

Intracranial AneurysmTranscriptomeAdultAgedCase-Control StudiesCircle of WillisFemaleHumansMaleMiddle AgedMiddle Cerebral ArteryTemporal ArteriesCerebral vasculatureIntracerebral arteryIntracranial aneurysmSuperficial temporal artery

Identifiers

PMID37612482
PMCPMC12646690
OpenAlexW4386100039

What Socratic holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.