Evidence map›Paper›PMID 37615707›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

Pylorus ligation-induced hyperacidity: synergistic prophylactic effects of linagliptin and L-arginine via up-regulation of EP4 receptor subtype and improvement of vascular endothelial damage.

Gihan F Asaad, Dalia O Saleh, Rasha E Mostafa, Azza Hassan, Gehad Abdel Jaleel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gihan F AsaadPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), 33 ELBohouth St. (Former EL Tahrir St.), P.O. 12622, Dokki, Cairo, Egypt.ORCID 0000-0002-7679-5968
Dalia O SalehPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), 33 ELBohouth St. (Former EL Tahrir St.), P.O. 12622, Dokki, Cairo, Egypt.ORCID 0000-0002-5401-5422
Rasha E MostafaPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), 33 ELBohouth St. (Former EL Tahrir St.), P.O. 12622, Dokki, Cairo, Egypt. re.mostafa@nrc.sci.eg.ORCID 0000-0002-5765-350X
Azza HassanPathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.ORCID 0000-0001-7641-3504
Gehad Abdel JaleelPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), 33 ELBohouth St. (Former EL Tahrir St.), P.O. 12622, Dokki, Cairo, Egypt.ORCID 0000-0003-2445-3314
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric hyperacidity and ulceration are chronic diseases characterized by repeated healing followed by re-exacerbation. The study aims to protect against gastric hyperacidity without interfering with gastric acid secretion. Pylorus ligation-induced hyperacidity is commonly utilized in the induction of gastric ulcers.Forty-two rats were distributed into seven groups (n = 6). Group I comprised sham-operated group. Group II served as pylorus-ligation group. Groups III-VII were given oral Linagliptin (LN; 3 and 6 mg/kg), L-arginine (LA; 150 and 300 mg/kg) and their combination (LN 3 + LA 150 mg/kg), respectively for 7 days. On the 8

Indexed as

PylorusStomach UlcerAnimalsArginineGastric MucosaLigationLinagliptinRatsUp-RegulationVascular Endothelial Growth Factor AArginineLinagliptinVascular Endothelial Growth Factor AHyperacidityL-arginineLinagliptinPylorus ligationRatsStomach

Identifiers

PMID37615707
PMCPMC10791926
OpenAlexW4386116316

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.