Evidence map›Paper›PMID 37619450›Full record

SynthesisEBioMedicine2023

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.

Benjamin G Faber, Monika Frysz, Cindy G Boer, Daniel S Evans, Raja Ebsim, Kaitlyn A Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R Saunders and 12 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. The complexity of pain in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  3. HiFiMAP: High-resolution fast identity-by-descent mapping test.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 5 countries.

Benjamin G FaberMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK. Electronic address: ben.faber@bristol.ac.uk.
Monika FryszMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
Cindy G BoerDepartment of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, USA.
Raja EbsimDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
Kaitlyn A FlynnMater Research Institute, The University of Queensland, Woolloongabba, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
Mischa LundbergUQ Frazer Institute, The University of Queensland, Woolloongabba, Australia.
Lorraine SouthamInstitute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
April HartleyMedical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
Fiona R SaundersCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
Claudia LindnerDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
Jennifer S GregoryCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
Richard M AspdenCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, UK.
Nancy E LaneCenter for Musculoskeletal Health, University of California Davis, Sacramento, USA.
Nicholas C HarveyMedical Research Council Lifecourse Epidemiology Centre, University of Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK.
David M EvansMedical Research Council Integrative Epidemiology Unit at the University of Bristol, UK; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia; UQ Frazer Institute, The University of Queensland, Woolloongabba, Australia.
Eleftheria ZegginiInstitute of Translational Genomics, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany; Technical University of Munich and Klinikum Rechts der Isar, TUM School of Medicine, Germany.
George Davey SmithMedical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
Timothy CootesDivision of Informatics, Imaging and Data Sciences, The University of Manchester, UK.
Joyce Van MeursDepartment of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands.
John P KempMedical Research Council Integrative Epidemiology Unit at the University of Bristol, UK; Mater Research Institute, The University of Queensland, Woolloongabba, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
Jonathan H TobiasMusculoskeletal Research Unit, University of Bristol, UK; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
The University of Queensland · AUUniversity of Aberdeen · GBUniversity of Manchester · GBBristol City Council · GBErasmus University Rotterdam · NLUniversity of Bristol · GBHelmholtz Zentrum München · DESouthmead Hospital · GBTUM Klinikum · DEUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of California, Davis · US

Funding

Study of Osteoporotic FracturesR01AG005407 · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1986 to 2005
$8.5M
STUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · KAISER FOUNDATION RESEARCH INSTITUTE · 1986 to 2005
$3.2M
Study of Osteoporotic FracturesR01AG005394 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1986 to 2005
$2.5M
Study of Osteoporotic FracturesR01AR035582 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1986 to 2005
$2.4M
Study of Osteoporotic FracturesR01AR035584 · UNIVERSITY OF MARYLAND BALTIMORE · 1986 to 2005
$2.1M
The Epidemiology and Genetics of Hip OA in Elderly MenR01AR052000 · UNIVERSITY OF CALIFORNIA DAVIS · 2005 to 2005
$544k
Midcareer Investigator Award Patient-Oriented ResearchK24AR048841 · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 2002 to 2005
$536k
Medical Research Council MC_PC_21003Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00032/1Medical Research Council MR/S00405X/1Medical Research Council MR/S021280/1NCATS NIH HHS UL1 TR000128NIAMS NIH HHS K24 AR048841NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR052000NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIA NIH HHS U24 AG051129Wellcome Trust 223267
6 · The paper itself

Abstract

backgroundHip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJSW loci convey hip osteoarthritis (HOA) risk and would therefore be of therapeutic interest.

methodsGWAS meta-analysis of hip mJSW derived from plain X-rays and DXA was performed, stratified by sex and adjusted for age and ancestry principal components. Mendelian randomisation (MR) and cluster analyses were used to examine causal effect of mJSW on HOA.

findings50,745 individuals were included in the meta-analysis. 42 SNPs, which mapped to 39 loci, were identified. Mendelian randomisation (MR) revealed little evidence of a causal effect of mJSW on HOA (OR INTERPRETATIONS: One group of mJSW loci reduce HOA risk via increased mJSW, suggesting possible utility as targets for chondroprotective therapies. The second group of mJSW loci increased HOA risk, despite increasing mJSW, but were also positively related to height, suggesting they contribute to HOA risk via a growth-related mechanism.

fundingPrimarily funded by the Medical Research Council and Wellcome Trust.

Indexed as

Genome-Wide Association StudyOsteoarthritis, HipCluster AnalysisHumansJointsMendelian Randomization AnalysisCartilageGenome-wide association studyMendelian randomisationOsteoarthritis

Identifiers

PMID37619450
PMCPMC10470292
OpenAlexW4386064614

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.