Evidence map›Paper›PMID 37620150›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2023

Chemogenetic activation of the ventral subiculum-BNST pathway reduces context fear expression.

Leeza Kopaeva, Alexandrina Yakimov, Louise Urien, Elizabeth P Bauer

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Leeza Kopaeva *Department of Biology, Barnard College of Columbia University, New York, New York 10027, USA.
Alexandrina Yakimov *Department of Biology, Barnard College of Columbia University, New York, New York 10027, USA.
Louise UrienDepartment of Biology, Barnard College of Columbia University, New York, New York 10027, USA.
Elizabeth P BauerDepartment of Biology, Barnard College of Columbia University, New York, New York 10027, USA ebauer@barnard.edu.
Columbia University · US

Funding

Regulation of fear conditioning by subicular inputs to the BNSTR15MH122969 · NIMH · BARNARD COLLEGE · PI BAUER, ELIZABETH P · 2020 to 2020
$411k
NIMH NIH HHS R15 MH122969
6 · The paper itself

Abstract

An inability to reduce fear in nonthreatening environments characterizes many anxiety disorders. The pathway from the ventral subiculum (vSUB) to the bed nucleus of the stria terminalis (BNST) is more active in safe contexts than in aversive ones, as indexed by FOS expression. Here, we used chemogenetic techniques to specifically activate the vSUB-BNST pathway during both context and cued fear expression by expressing a Cre-dependent hM3D(Gq) receptor in BNST-projecting vSUB neurons. Activation of the vSUB-BNST pathway reduced context but not cued fear expression. These data suggest that the vSUB-BNST pathway contributes to behavioral responses to nonaversive contexts.

Indexed as

HippocampusSeptal NucleiAnxiety DisordersCuesFearHumans

Identifiers

PMID37620150
PMCPMC10519403
OpenAlexW4386119191

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.