Evidence map›Paper›PMID 37620514›Full record

ArticleScientific reports2023

C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.

Misato Kobayashi, Fumi Kanbe, Reika Ishii, Hiroki Tsubouchi, Kana Hirai, Yuki Miyasaka, Tamio Ohno, Hiroaki Oda, Saiko Ikeda, Hirokazu Katoh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Misato KobayashiDepartment of Nutritional Sciences, Nagoya University of Arts and Sciences, 57 Takenoyama, Iwasaki-Cho, Nisshin, Aichi, 470-0196, Japan. misato@nuas.ac.jp.
Fumi KanbeDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Reika IshiiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Hiroki TsubouchiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Kana HiraiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Yuki MiyasakaDivision of Experimental Animals, Graduate School of Medicine, Nagoya University, Aichi, Japan.
Tamio OhnoDivision of Experimental Animals, Graduate School of Medicine, Nagoya University, Aichi, Japan.
Hiroaki OdaDepartment of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Saiko IkedaDepartment of Nutritional Sciences, Nagoya University of Arts and Sciences, 57 Takenoyama, Iwasaki-Cho, Nisshin, Aichi, 470-0196, Japan.
Hirokazu KatohDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Kenji IchiyanagiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Akira IshikawaDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Atsushi MuraiDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Fumihiko HorioDepartment of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
Nagoya University · JPNagoya University of Arts and Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High serum levels of triglycerides (TG) and low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of coronary heart disease in humans. Herein, we first reported that the C3H/HeNSlc (C3H-S) mouse, a C3H/HeN-derived substrain, is a novel model for dyslipidemia. C3H-S showed hypertriglyceridemia and low total cholesterol (TC), HDL-C, and phospholipid (PL) concentrations. To identify the gene locus causing dyslipidemia in C3H-S, we performed genetic analysis. In F2 intercrosses between C3H-S mice and strains with normal serum lipids, the locus associated with serum lipids was identified as 163-168 Mb on chromosome 2. The phospholipid transfer protein (Pltp) gene was a candidate gene within this locus. Pltp expression and serum PLTP activity were markedly lower in C3H-S mice. Pltp expression was negatively correlated with serum TG and positively correlated with serum TC and HDL-C in F2 mice. Genome sequencing analysis revealed that an endogenous retrovirus (ERV) sequence called intracisternal A particle was inserted into intron 12 of Pltp in C3H-S. These results suggest that ERV insertion within Pltp causes aberrant splicing, leading to reduced Pltp expression in C3H-S. This study demonstrated the contribution of C3H-S to our understanding of the relationship between TG, TC, and PL metabolism via PLTP.

Indexed as

DyslipidemiasPhospholipid Transfer ProteinsAnimalsCholesterol, HDLEndogenous RetrovirusesHumansMiceMice, Inbred C3HTriglyceridesCholesterol, HDLphospholipid transfer protein, mousePhospholipid Transfer ProteinsTriglycerides

Identifiers

PMID37620514
PMCPMC10449841
OpenAlexW4386137006

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.