ReviewNature reviews. Neuroscience2023
A biophysical perspective on the resilience of neuronal excitability across timescales.
Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Machine learning-assisted self-powered ear tag for animal welfare.Nature communications · 2026Article
- Neuronal excitability and parameter variability in the Hodgkin-Huxley model.PLoS computational biology · 2026Article
- Distributional invariance and proportional scaling in axonal conduction.Biophysical journal · 2026Article
- Feedback neurons based on perovskite memristor with nickel single-atom engineered reduced graphene oxide cathode.Nature communications · 2026Article
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026Article
- Adaptation modulates effective connectivity and network stability.Frontiers in computational neuroscience · 2026Article
- Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.Nature communications · 2025Article
- Noninvasive profiling of input-output excitability curves in human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- A Neural Model for V1 That Incorporates Dendritic Nonlinearities and Backpropagating Action Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Resilience and brain health in global populations.Nature medicine · 2025Review
- Metaplasticity and continual learning: mechanisms subserving brain computer interface proficiency.Journal of neural engineering · 2025Article
- Antifragile control systems in neuronal processing: a sensorimotor perspective.Biological cybernetics · 2025Review
- Life sets off a cascade of machines.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.Scientific reports · 2024Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.BMC biology · 2024Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.bioRxiv : the preprint server for biology · 2024Article
- Resilience of circuits to environmental challenge.Current opinion in neurobiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal membrane excitability must be resilient to perturbations that can take place over timescales from milliseconds to months (or even years in long-lived animals). A great deal of attention has been paid to classes of homeostatic mechanisms that contribute to long-term maintenance of neuronal excitability through processes that alter a key structural parameter: the number of ion channel proteins present at the neuronal membrane. However, less attention has been paid to the self-regulating 'automatic' mechanisms that contribute to neuronal resilience by virtue of the kinetic properties of ion channels themselves. Here, we propose that these two sets of mechanisms are complementary instantiations of feedback control, together enabling resilience on a wide range of temporal scales. We further point to several methodological and conceptual challenges entailed in studying these processes - both of which involve enmeshed feedback control loops - and consider the consequences of these mechanisms of resilience.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.