ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Prospective study on physical activity and Alzheimer's disease-related biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study.The lancet. Healthy longevity · 2025Article
- Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins.Aging brain · 2025Article
- Heritability of Alzheimer's disease plasma biomarkers: A nuclear twin family design.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men.The journal of pain · 2024Article
- Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.Age and ageing · 2024Article
- The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cross-sectional study of plasma phosphorylated tau 217 in persons without dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
introductionDespite their increased application, the heritability of Alzheimer's disease (AD)-related blood-based biomarkers remains unexplored.
methodsPlasma amyloid beta 40 (Aβ40), Aβ42, the Aβ42/40 ratio, total tau (t-tau), and neurofilament light (NfL) data came from 1035 men 60 to 73 years of age (μ = 67.0, SD = 2.6). Twin models were used to calculate heritability and the genetic and environmental correlations between them.
resultsAdditive genetics explained 44% to 52% of Aβ42, Aβ40, t-tau, and NfL. The Aβ42/40 ratio was not heritable. Aβ40 and Aβ42 were genetically near identical (r DISCUSSION: Except for Aβ42/40, plasma biomarkers are heritable. Aβ40 and Aβ42 share mostly the same genetic influences, whereas genetic influences on plasma t-tau and NfL are largely unique in early old-age men. The absence of genetic associations between the Aβs and t-tau is not consistent with the amyloid cascade hypothesis.
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Registered trials
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